Using stem cells from umbilical cords to treat lung disease in premature infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the safety and efficacy of umbilical cord-derived mesenchymal stem cell (MSC) transplantation for treating bronchopulmonary dysplasia (BPD) in premature infants. BPD is a serious lung condition that affects very low and ultra-low birth weight infants, leading to long-term health issues. The study aims to assess whether MSCs can improve lung function and reduce inflammation in these infants who have not responded to standard treatments. Participants will be closely monitored for improvements in their lung condition and overall health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 23-29 weeks of gestation, birth weight 500-1500g;
2. For patients with no improvement or aggravation of lung condition after DART hormone therapy, and positive pressure ventilation by tracheal intubation is still required at a correct gestational age of 36 weeks.
3. Children with severe BPD after early use of PS
4. Parents agree to participate in clinical trials.

Exclusion Criteria:

1. Premature infants not suitable for the given gestational age;
2. Other congenital structural malformations of trachea, bronchus and lungs;
3. Complicated with severe congenital heart disease;
4. Complicated with Periventricular Leukomalacia (PVL);
5. Complicated with intraventricular hemorrhage (IVH) above level 3;
6. Septic shock or positive blood culture;
7. Acute pulmonary hemorrhage;
8. Intracranial and extracranial diseases affecting respiratory rate and rhythm.

Where it's running

• The Children's Hospital of Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Yaoqin Hu, MD
• Email: huyaoqin@zju.edu.cn
• Phone: 0571-86670704

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Enteral DHA and ARA Supplementation for Very Preterm Infants with BPD Risk

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• Continuing CPAP protection for extremely preterm babies to reduce BPD or death

  This study tests whether keeping CPAP up to 34 weeks' PMA or for at least 2 more weeks, instead of weaning to a nasal cannula, lowers the chance of bronchopulmonary dysplasia or death by 36 weeks' PMA in babies born before 29 weeks gestation.

  Recruiting at 15 sites NICHD Neonatal Research Network · Birmingham, Alabama and 14 other locations · NCT07417111

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.