Using speech analysis to understand emotions, movement, and cognition in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the potential of computerized speech analysis to objectively detect fluctuations in motor function, emotional state, and cognitive processes in patients with Parkinson's disease. By analyzing speech patterns, the researchers aim to gain insights into how these three aspects are affected by the disease and its treatments, including medication and deep brain stimulation. The study will also include healthy subjects as a control group to compare speech changes in different contexts. The goal is to improve therapy management for Parkinson's patients through detailed analysis of their speech.

Why it matters

Who can join: the full rules

Patients with Parkinson's Disease

Inclusion Criteria:

* Written informed consent
* Idiopathic PD according to the Movement Disorders Society Criteria;
* Age of participants \> 30 and ≤ 75 years;
* Treatment with or without bilateral deep brain stimulation in the subthalamic nucleus;
* Fluent in German or French

Exclusion Criteria:

* Dysarthria caused in addition by a condition other than PD (e.g. stroke, myasthenia);
* Clinical diagnosis of aphasia;
* Brain disease other than Parkinson's disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.).
* Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points);
* Depression with acute suicidal ideation

Healthy Controls

Inclusion Criteria:

* Written informed consent
* Adults from 50-70 years old;
* Fluent in German or French

Exclusion Criteria:

* Diagnosis of Parkinson's disease;
* Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points);
* Suffering from brain disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.);
* Clinical diagnosis of aphasia, dysarthria, and stuttering;
* Suffering from or diagnosed with psychiatric illnesses according to DSM-V criteria

Where it's running

• University Hospital Inselspital, Berne
  Bern, Switzerland Recruiting
• Czech Technical University Prague
  Prague, Czechia Active not recruiting

Study contacts

• Principal investigator: Paul Krack, Prof. — Insel Gruppe AG, University Hospital Bern
• Study coordinator: Paul Krack, Prof.
• Email: paul.krack@insel.ch
• Phone: 31 66 4 03 71

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.