Using spectral methods to improve IVF success rates
Application of Spectral Methods to Assess the Potential of Gametes and Embryos, as Well as Human Reproductive Capabilities
This study is testing a new system that uses special data to see if it can help improve success rates for people undergoing IVF by better predicting which embryos are most likely to succeed.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1064 (estimated) |
| Ages | 20 Years to 44 Years |
| Sex | All |
| Sponsor | Family Planning Center of Women's Welfare Clinic #44 of Pushkin District Government |
| Locations | 1 site (Saint Petersburg, Pushkin) |
| Trial ID | NCT06266169 on ClinicalTrials.gov |
What this trial studies
This study aims to develop a system that assesses and predicts the potential of gametes and embryos, as well as human reproductive capabilities, using spectral data. It consists of two stages: a retrospective analysis to build a machine learning model based on historical data, and a prospective stage to validate the model's effectiveness in making clinical decisions during infertility treatment with IVF. The goal is to enhance the efficiency of assisted reproductive technologies and reduce complications associated with multiple embryo transfers.
Who should consider this trial
Good fit: Ideal candidates include individuals undergoing IVF treatment with embryos that have reached the blastocyst stage and sperm samples used for fertilization.
Not a fit: Patients with ectopic pregnancies or those with only one blastocyst that is predicted to be negative by the model will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve IVF success rates and reduce the incidence of miscarriages.
How similar studies have performed: While there have been various approaches to embryo selection, this specific application of spectral methods combined with machine learning is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Embryos: embryos that have reached the blastocyst stage * Sperm: samples used for IVF during infertility treatment * Endometrium: endometrial spectra in cases where an embryo transfer was performed into the uterus Exclusion Criteria: * For all groups: ectopic pregnancy * Embryos: presence of only one blastocyst, and that embryo prognosed by the model as negative * Sperm: a cycle where less than 3 oocytes suitable for fertilization were obtained; total pathological fertilization; 60% or more immature oocytes at the time of fertilization registration
Where this trial is running
Saint Petersburg, Pushkin
- Family planning center — Saint Petersburg, Pushkin, Russian Federation (Recruiting)
Study contacts
- Principal investigator: Alexey Gryaznov — Family planning center of SPB SBHI "Maternity welfare clinic" #44 of Pushkin district
- Study coordinator: Alexey Gryaznov
- Email: libra19831010@mail.ru
- Phone: +7(812)414-57-11
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.