Using special dialysis membranes to reduce itching in kidney patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of polymethylmethacrylate (PMMA) membranes in reducing pruritus in patients with chronic kidney disease stage 5D undergoing maintenance hemodialysis. Participants will be randomly assigned to receive either PMMA or standard polysulfone membranes for a duration of two months. Throughout the study, patients will complete questionnaires to assess the intensity of their itching and its impact on their quality of life. The goal is to determine if PMMA membranes can significantly alleviate moderate-to-severe pruritus compared to traditional membranes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of CKD stage 5D, maintenance hemodialysis not less than 3 months prior screening;
* Moderate-to-severe pruritis (WI-NRS score ≥ 4);
* Adequate dialysis dose (spKt/V≥1,4 and/or eKt/V≥1,2);
* Dialysis treatment regimen: three sessions per week of at least 4 hours duration;
* Signed informed consent.

Exclusion Criteria:

* Presence of active skin disease, cholestasis, severe secondary hyperparathyroidism and other conditions that, in the investigator's opinion, may be responsible for pruritus.
* Noncompliance of the patient with the protocol (in the investigator's opinion).
* Use of haemodiafiltration.

Where it's running

• Saint Petersburg State University Hospital
  Saint Petersburg, Russia Recruiting

Study contacts

• Study coordinator: Ekaterina Parshina, PhD
• Email: pannn@yandex.ru
• Phone: +7(921)6577372

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.