Using robotics to improve motor skills in patients with acute stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research program investigates the ability of acute stroke patients to learn and retain complex motor skills using a rehabilitation robot called REAplan®. Over three days, participants will engage in training through serious games designed to enhance motor skill learning. The study aims to compare the performance of acute stroke patients with healthy individuals and chronic stroke patients, while also examining how different brain regions affected by stroke impact motor skill learning. Participants will be randomized into different groups to assess the effectiveness of various rehabilitation approaches.

Why it matters

Who can join: the full rules

ACUTE STROKE PATIENTS:

Inclusion Criteria:

* acute stroke (\> 21 days)
* aged 18-90 years
* with a stroke lesion on brain imaging

Exclusion Criteria:

* " classical " contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophoby, etc ...)
* difficulty in understanding or executing commands
* drug/alcohol abuse
* severe aphasia / cognitive deficits interfering with study
* inability to voluntarily move the affected arm (i.e. complete paralysis of the arm)
* multiple strokes / dementia / psychiatric condition

PATIENTS WITH TRANSIENT GLOBAL AMNESIA:

Clinical diagnosis, criteria of Hodge \& Warlow (1990):

* Anterograde amnesia observed by a witness
* No alteration of consciousness or loss of identity
* Cognitive dysfunction limited to amnesia
* Lack of focused neurological deficit or argument for a comitiality
* Absence of head trauma
* Symptom resolution within 24 hours
* Possible existence of vegetative symptoms

Inclusion criteria:

* Transient global amnesia
* 8-90 years old
* Be able to perform 3 consecutive sessions on a rehabilitation robot

Exclusion criteria:

* Severe aphasia / cognitive deficits interfering with study
* Psychiatric disorders
* Alcohol / drug addiction
* Exclusion criteria related to MRI

HEALTHY INDIVIDUALS:

Inclusion Criteria:

• 18-90 years

Exclusion Criteria:

* medical history with a previous stroke/neurological deficit
* drug/alcohol abuse
* psychiatric condition/ dementia

CHRONIC STROKE PATIENTS:

Inclusion Criteria:

* chronic stroke (\>6 months)
* aged 18-90 years
* with a stroke lesion on brain imaging

Exclusion Criteria:

* difficulty in understanding or executing commands
* drug/alcohol abuse
* severe aphasia / cognitive deficits interfering with study
* inability to voluntarily move the affected arm (i.e. complete paralysis of the arm)
* multiple strokes / dementia / psychiatric condition

Where it's running

• CHU UCL Namur
  Yvoir, Namur, Belgium Recruiting
• University Hospital CHU Dinant Godinne UCL
  Yvoir, Belgium Not yet recruiting

Study contacts

• Principal investigator: Yves Vandermeeren, MD, PhD — UCLouvain IONS
• Study coordinator: Yves Vandermeeren, MD, PhD
• Email: yves.vandermeeren@uclouvain.be
• Phone: +32 81 42 33 21

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Music therapy after stroke

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• Inter-Limb Transfer after Acute Stroke

  This study tests whether practicing motor skills with the affected arm helps improve movement in the other arm after an acute stroke.

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• Immersive Virtual Reality in Upper-Limb Rehabilitation After Stroke

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• Anakinra After Endovascular Therapy for Ischemic Stroke

  This trial tests whether giving two doses of Anakinra after successful endovascular treatment can reduce brain damage and improve outcomes in adults with acute ischemic stroke.

  Recruiting at 6 sites Phase 2 Beijing Tiantan Hospital · Beijing, Beijing Municipality and 5 other locations · NCT07423975

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.