Using remote ischemic conditioning to treat acute moderate posterior ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of remote ischemic conditioning (RIC) on patients suffering from acute moderate posterior ischemic stroke. The approach involves administering RIC within 48 hours of stroke onset to potentially improve neurological outcomes. Previous studies have shown safety and some efficacy of RIC, but this trial aims to provide more robust evidence specifically for posterior circulation strokes. Participants will be monitored for improvements in their neurological status over a 90-day period following treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years;
* Time from onset to treatment: ≤48 hours;
* Posterior circulation ischemic stroke confirmed by CT or MRI, including patients who have received intravenous thrombolysis or endovascular therapy;
* NIHSS score at randomization: 6-16, with an item 1a (level of consciousness) score of 0-1;
* First-ever stroke or prior stroke without significant residual disability (modified Rankin Scale score ≤1);
* Signed informed consent.

Exclusion Criteria:

* intracerebral hemorrhage or subarachnoid hemorrhage；
* Uncontrolled severe hypertension (systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg despite antihypertensive therapy)；
* Subclavian artery stenosis ≥ 50% or subclavian steal syndrome;
* Intracranial tumor, arteriovenous malformation or aneurysm;
* Severe abnormalities in coagulation;
* Any contraindication for remote ischemic adaptation: the upper limb has serious soft tissue injury, fracture or vascular injury, distal upper limb perivascular lesions, etc.;
* Participating in other clinical trials within 3 months;
* Comorbidity with any serious diseases and life expectancy is less than half a year;
* Patients not suitable for this clinical studies considered by researcher;

Where it's running

• Department of Neurology, General Hospital of Northern Theater Command
  Shenyang, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.