Using remote ischemic conditioning to protect the brain after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the neuroprotective effects of remote ischemic post-conditioning (RIPOST) in patients who have experienced an out-of-hospital cardiac arrest. Participants will be randomly assigned to either an experimental group receiving standard care plus RIPOST sessions or a control group receiving standard care plus sham sessions. The RIPOST sessions involve cycles of limb ischemia and reperfusion aimed at reducing brain injury caused by ischemia-reperfusion syndrome. The study will last for 27 months, with patient participation lasting 3 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Out-of-hospital cardiac arrest with stable return of spontaneous circulation (ROSC \> 20 minutes)
* Patient receiving invasive mechanical ventilation for coma (Glasgow score \< 8)
* Availability of a lower limb without intravenous infusion or tension cuff positioned on it
* Randomization and application of the first session of the tested procedure within 4 hours after ROSC
* Consent of a next-of-kin or inclusion in emergency procedure

Exclusion criteria :

* Age \< 18 y.o or pregnancy
* Patient unable to walk without assistance, unable to support himself properly without assistance, bedridden, incontinent and requiring nursing constant attention and care (corresponding to a mRS equal to 4 or 5)
* Interval between cardiac arrest and ROSC (no flow + low flow) estimated \> 60 minutes
* Unwitnessed cardiac arrest with asystole as first rhythm
* In-hospital cardiac arrest
* Refractory cardiac arrest (no ROSC considered as stable)
* Cardiac arrest from traumatic, hemorrhage, stroke or hanging supposed origin
* Mean arterial pressure \< 65mmHg persisting despite appropriate vascular filling and vasopressor and/or inotropic support
* Active uncontrolled bleeding
* Contraindication or not possible to use a pneumatic tourniquet on none of the two lower limbs (amputations, intravenous infusion positioned on both lower limbs, tourniquet size incompatible with patient morphology)
* Implementation of extracorporeal arteriovenous circulation for refractory cardiac arrest or refractory cardiogenic shock before inclusion
* Patient already included in this study
* Inclusion in another interventional study which purpose is to improve prognosis after a cardiac arrest
* Judicial protection measure
* Patient without French social security

Where it's running

• Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer
  Toulon, Var, France Recruiting

Study contacts

• Study coordinator: Chelly Jonathan, MD
• Email: Jonathan.chelly@ch-toulon.fr
• Phone: 0494145124

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Initial double sequential defibrillation for out-of-hospital ventricular fibrillation

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.