Using radiation therapy to prevent Dupuytren's contracture recurrence after treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of targeted radiation therapy in preventing the recurrence of Dupuytren's contracture following a non-surgical release using Collagenase Clostridium Histolyticum. Participants aged 45 and older with advanced Dupuytren's contracture will receive radiation therapy for five days after their initial treatment, followed by a rest period and another five days of radiation. The study will monitor patients for any recurrence of contracture and assess the safety and tolerability of the combined treatment approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 45 or greater with DC
* Extension deficit \>10 degrees
* Unable to simultaneously place the affected finger and palm flat on a table.
* Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
* For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included

Exclusion Criteria:

* Unsuccessful non-surgical release (\> N/1 disease)
* They develop an open wound during CCH
* Breast feeding or pregnancy
* A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
* Less than the age of 45
* They have previously undergone radiation on the hand in which they plan to get CCH injections
* They are pregnant women, impaired adults or prisoners

Where it's running

• Dartmouth Hitchcock
  Lebanon, New Hampshire, United States Recruiting

Study contacts

• Principal investigator: Lance Warhold, MD — Dartmouth Health
• Study coordinator: Peter A DePalo, BS, CCRP
• Email: peter.a.depalo.sr@hitchcock.org
• Phone: 603 653-0494

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• CNT201 collagenase injection for Dupuytren’s: safety and signals of efficacy in adults

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• Evaluating a new ultrasound-guided technique for Dupuytren's contracture

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• Treatment options for Dupuytren's contracture

  This study is testing whether adding a corticosteroid injection to a needle treatment helps people with Dupuytren's contracture move their fingers better.

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• Evaluating night splinting after needle fasciotomy for Dupuytren's contracture

  This study is testing if wearing a night splint after a needle procedure for Dupuytren's contracture can help prevent the condition from coming back compared to just physical therapy alone.

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• Evaluating post-surgery radiation treatment for Dupuytren's disease

  This study is testing whether adding radiation treatment after surgery for Dupuytren's disease can help improve hand function and reduce symptoms for patients.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04122313

• Surgical technique to reduce scarring in trigger finger patients with Dupuytren's cord

  This study is testing a new surgical method to help people with trigger finger and Dupuytren's cord heal better with less scarring after surgery.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03155854

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.