Using radiation therapy before chemotherapy for Luminal B breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The IBISCO TRIAL is designed to evaluate the effectiveness of stereotactic radiation therapy (SBRT) as a preoperative boost in patients with Luminal B breast cancer undergoing neoadjuvant chemotherapy. This phase II trial aims to improve the rate of pathological complete response (pCR) by treating patients with SBRT prior to surgery. Thirty patients with clinical stage T1-2 Luminal B breast cancer will be enrolled over two years, and their surgical specimens will be analyzed for residual cancer burden. Additionally, the study will include a cohort of patients who meet the criteria but choose not to participate in the interventional group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Luminal B-like BC, cT1-2
* Indication for neoadjuvant chemotherapy

Exclusion Criteria:

* Pregnancy
* Breast feeding
* Patient not available for follow up

Where it's running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna
  Bologna, Italy Recruiting

Study contacts

• Principal investigator: Alessio G Morganti, MD, PhD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
• Study coordinator: Alice Zamagni, MD
• Email: alice.zamagni4@unibo.it
• Phone: +39 0512143564

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing two types of radiation therapy for breast cancer patients

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.