Using pulsed electromagnetic fields to treat knee osteoarthritis

A Double-Blinded, Randomized-Control-Trial to Investigate the Effect of Pulsed Electromagnetic Field (PEMF) for Patients With Knee Osteoarthritis

NA · Chinese University of Hong Kong · NCT05548712

This study tests if pulsed electromagnetic field therapy can help older adults with knee osteoarthritis and chronic pain recover better when combined with exercise.

Quick facts

PhaseNA
Study typeInterventional
Enrollment80 (estimated)
Ages50 Years and up
SexAll
SponsorChinese University of Hong Kong (other)
Locations1 site (Hong Kong)
Trial IDNCT05548712 on ClinicalTrials.gov

What this trial studies

This study investigates the effects of pulsed electromagnetic field (PEMF) therapy on patients suffering from knee osteoarthritis (OA) and chronic knee pain. It aims to assess whether PEMF can enhance muscle regeneration and tissue healing when combined with regular exercise. The study will include participants aged 50 and above with specific grades of knee OA, focusing on those with a sedentary lifestyle. Participants will be randomly assigned to receive either active PEMF treatment or a sham treatment to evaluate the efficacy of the intervention.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 50 and older with knee osteoarthritis classified as Kellgren-Lawrence grade 2-4 and who lead a sedentary lifestyle.

Not a fit: Patients under 50 years old or those with significant knee injuries or other rheumatological diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a cost-effective and non-invasive option for managing knee osteoarthritis and improving mobility in affected patients.

How similar studies have performed: While PEMF therapy is gaining attention, this specific approach for knee osteoarthritis is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age 50 or above
2. knee OA with Kellgren-Lawrence grade 2-4 by X-ray
3. Sedentary lifestyle (Tegner activity level ≤ 3)
4. No acute knee injuries in past 12 months
5. No muscle strain in past 12 months
6. No degenerative joint diseases in other joints except the involved knee

Exclusion Criteria:

1. Age smaller than 50 years old
2. Experienced any concomitant bone fracture, ACL injury, major meniscus injury
3. Any rheumatological diseases
4. Metal implants that would cause interference on MRI
5. Previous contralateral knee injury
6. Recent knee injections (prior 3 months)
7. Physical inability to undertake testing procedures
8. Pregnancy or possibility of pregnancy

Where this trial is running

Hong Kong

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Knee Osteoarthritis, Knee Pain Chronic, Pulse electromagnetic field, PEMF, Knee OA, Knee pain

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.