Using probiotics with clobetasol for treating oral lichen planus
Evaluation of the Efficacy of Supplementary Probiotic Capsules With Topical Clobetasol Propionate 0.05% in the Treatment of Oral Lichen Planus
This study is testing if adding probiotic capsules to a common treatment for oral lichen planus can help patients feel better compared to just using the standard treatment alone.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 20 Years to 75 Years |
| Sex | All |
| Sponsor | October 6 University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06119672 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of probiotic capsules combined with topical clobetasol propionate in treating patients with oral lichen planus. Participants will be randomly assigned to either an intervention group receiving probiotics and clobetasol or a control group receiving clobetasol and miconazole gel. The study will last for four weeks, with salivary samples collected at the beginning and end to assess treatment effects. The goal is to determine if the addition of probiotics enhances the therapeutic outcomes compared to standard treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20-75 diagnosed with symptomatic oral lichen planus.
Not a fit: Patients with systemic disorders affecting the immune system or those with active liver diseases and cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a more effective treatment option for patients suffering from oral lichen planus.
How similar studies have performed: While the combination of probiotics and corticosteroids is a novel approach, similar studies have shown promise in other conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are diagnosed with symptomatic lichen planus whether bullous erosive or erythematous oral lichen planus. * Male or female patient with age range between 20-75 years old were included. * medically free individuals Exclusion Criteria: * the use of systemic antibiotics, corticosteroids or immunosuppressive agents within four weeks prior to enrollment in the study. * Pregnant females * patients with history of systemic disorder affecting the immune system * active liver diseases and cancer * allergy or intolerance to probiotics. * any other oral lesions
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: yasmine kamal, lecturer — Cairo University
- Study coordinator: Amira Abdelwhab, lecturer
- Email: amira.abdelwhab.dent@o6u.edu.eg
- Phone: 01007647877
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.