Using probiotics to treat abdominal pain in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of Lactobacillus GG, a type of probiotic, on children aged 6-15 who suffer from functional abdominal pain disorders, such as irritable bowel syndrome. The study aims to determine whether this probiotic can alleviate symptoms and improve the quality of life for these children. Participants will be divided into two groups, receiving either the probiotic or a placebo, to assess the effectiveness of the treatment. The trial is designed to provide insights into the role of the microbiome in managing abdominal pain in pediatric patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children, aged 6-15 years old, with a diagnosis of IBS or FAP, according to the Rome IV diagnostic criteria. The diagnosis of IBS or FAP was based on a clinical interview performed by pediatric gastroenterologist.

For healthy controls: non-obese children, aged 6-15 years old, without any gastrointestinal symptoms at the time of recruitment.

Exclusion Criteria:

* Children who

  1. had any chronic diseases, including neurobehavioral disorders
  2. received treatment with antibiotics/probiotics in the previous 2 months
  3. received medication that affects gastrointestinal motility in the previous 1 week
  4. had a pain history suggestive of functional dyspepsia/aerophagia/abdominal migraine/functional constipation
  5. exhibited growth failure
  6. had gastrointestinal obstructions/stricture
  7. displayed alarming signs of organic condition
  8. had previous abdominal surgery
  9. had abnormal baseline test results as part of their standard work-up (e.g. complete blood counts; erythrocyte sedimentation rate; liver-pancreas-kidney function tests; stool examination for occult blood, ova, and parasites; fecal calprotectin; urinalysis; abdominal ultrasound; 13C-urea breath test; gastric emptying study, if any)
  10. had family history of peptic ulcer disease or inflammatory bowel disease

Where it's running

• Atchariya Chanpong
  Songkhla, Thailand Recruiting

Study contacts

• Study coordinator: Atchariya Chanpong, M.D, Ph.D.
• Email: atchariya.c@psu.ac.th
• Phone: 6674451250

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.