Using probiotics to improve gum health and reduce bad breath
Evaluating The Effect of Probiotics on Oral Health Status and Its Influence on The Gingival Disease and Halitosis in Iraq
This study is testing if taking probiotics can help young adults aged 17-25 improve their gum health and reduce bad breath.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 17 Years to 25 Years |
| Sex | All |
| Sponsor | Al-Mustansiriyah University Academic / other |
| Locations | 1 site (Bagdad) |
| Trial ID | NCT06910397 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the impact of probiotics on oral health, specifically targeting gingivitis and halitosis in young adults aged 17-25. Participants will be randomly assigned to receive either probiotics or a placebo for 28 days. The study will measure salivary biomarkers, including cytokine IL-1b and matrix metalloproteinase (MMP-8), as well as volatile sulfur compounds (VSCs) to assess improvements in gingival health. Statistical analyses will compare the outcomes between the two groups at different intervals.
Who should consider this trial
Good fit: Ideal candidates are healthy males and females aged 17-25 with specific oral health conditions, including mouth breathing habits and orthodontic or prosthodontic appliances.
Not a fit: Patients with chronic or systemic diseases, autoimmune conditions, or those currently on antibiotics will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to effective probiotic treatments for improving gum health and reducing bad breath.
How similar studies have performed: While the use of probiotics for oral health is a growing area of interest, this specific approach targeting gingivitis and halitosis in this demographic is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
The Inclusion criteria * Subjects (male and female) between the age range 17-25 years old. * Subjects with mouth breathing habit. * Subjects with orthodontic and prosthodontic appliance * Race from Iraq. * Subjects having a dentition with ≥20 evaluable teeth (minimum of five teeth per quadrant). The Exclusion criteria * History of chronic disease. * History of systemic disease. * Patients with autoimmune diseases. * Patients under antibiotic treatment. * Pregnant, lactating females. * History of undergoing nonsurgical and surgical periodontal therapy in the last 6 months.
Where this trial is running
Bagdad
- AL- Mustansiriyah University College of Dentistry — Bagdad, Iraq (Recruiting)
Study contacts
- Principal investigator: BAYDAA Y Alani, MSc student
- Study coordinator: Mohammed I Alzubidi, Supervisor
- Email: MDPL3MIA@uomustansiriyah.edu.iq
- Phone: 009647811199777
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.