Using probiotics to enhance healing after tooth extractions
Efficacy of Probiotics in Improving Post-surgical Healing for Impacted Tooth Extractions
NA · University of Pisa · NCT04903925
This study is testing if taking Lactobacillus reuteri probiotics can help people heal better after having their impacted teeth removed and reduce stomach issues from antibiotics.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pisa (other) |
| Locations | 1 site (Pisa) |
| Trial ID | NCT04903925 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of Lactobacillus reuteri probiotics in improving wound healing following impacted tooth extractions. It is a randomized, double-blind, placebo-controlled study that aims to assess both the primary outcome of post-extractive healing and the secondary outcome of reducing gastrointestinal symptoms associated with antibiotic therapy. Participants will receive either the probiotic or a placebo alongside standard care, allowing for a comparison of outcomes. The study seeks to provide insights into the role of probiotics in dental recovery and antibiotic side effects.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who require impacted tooth extractions and can provide informed consent.
Not a fit: Patients with allergies to penicillin, contraindications to oral surgery, or those who are immunocompromised may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved healing and reduced gastrointestinal complications for patients undergoing tooth extractions.
How similar studies have performed: Previous studies have shown promising results for the use of Lactobacillus reuteri in dental healing, suggesting potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * need for impacted tooth extractions * over age 18 * ability to understand and to sign an informed consent form Exclusion Criteria: * allergy to penicillin * contraindications to oral surgery * treatment with immunosuppressive agents or immunocompromised * treatment with amino-bisphosphonate and anti-angiogenetic medications * irradiation to head and neck area * uncontrolled diabetes * renal failure * drug and alcohol addiction * psychiatric disorders
Where this trial is running
Pisa
- U.O. Odontostomatologia e Chirurgia del Cavo Orale — Pisa, Italy (RECRUITING)
Study contacts
- Principal investigator: Antonio Barone, Professor — University of Pisa
- Study coordinator: Antonio Barone, Professor
- Email: antonio.barone@unipi.it
- Phone: 050993327
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Probiotics, Tooth, Impacted, Wound Heal, Gastrointestinal Complication