Using prednisolone to treat respiratory tract infections in hospitalized adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness and safety of prednisolone in treating moderate to severe respiratory tract infections in adults who are hospitalized. Participants will receive either prednisolone 30 mg or a placebo daily for five days, and their symptoms will be monitored through daily diaries and follow-up calls over 30 days. The study will compare the outcomes between the two groups, focusing on the incidence of sepsis and overall survival rates. A total of 1300 patients will be recruited from emergency departments and wards in Hong Kong.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients will be eligible for the study if ALL the following are present:

1. Adults ≥18 years of age; AND
2. scARI; AND
3. Intended hospitalisation; AND
4. No medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial

Exclusion Criteria:

Patients will be excluded if the treating clinician considers that the patient is not suitable for the trial.

Patients may be excluded if any ONE of the following are present:

1. Vulnerable subjects (pregnancy; cognitively impaired; prisoners; students; umemployee; minorities);
2. Cardiac arrest or post-cardiac arrest ROSC;
3. Not expected to survive 3 days due to pre-existing chronic disease;
4. Palliative (comfort) care
5. Undergoing active cancer therapy;
6. Neutropenia due to chemotherapy/malignancy (but not due to sepsis)
7. Immunocompromised or being treated with immunotherapy
8. Organ transplantation
9. HIV and on HIV drugs (indinavir, atazanavir, nelfinavir, saquinavir, ritonavir)
10. Recent Surgery (within one month)
11. Dialysis (including CAPD)
12. Diabetic ketoacidosis
13. Acute asthma
14. Recurrent chest infection,
15. Cushing's or Addisonian's disease,
16. Long term systemic steroid
17. Long-term antibiotics

Where it's running

• Queen Mary Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Timothy H Rainer — The University of Hong Kong
• Study coordinator: Timothy H Rainer, MD
• Email: thrainer@hku.hk
• Phone: 39176846

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.