Using platelet-rich plasma to treat knee osteoarthritis
Official title: Efectividad Del Plasma Rico en Plaquetas (PRP) Para la disminución Objetiva Del Dolor y la recuperación Funcional Del Miembro Inferior en Osteoartritis de Rodilla. Evaluación de Alternativas metodológicas
Run by Universidad Nacional de Entre Rios · NCT05825105 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing two different ways of using platelet-rich plasma to see which one helps people with knee osteoarthritis feel less pain and move better.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 35 Years and up |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | Universidad Nacional de Entre Rios Academic / other |
| Locations | 1 site (Oro Verde, Entre Ríos) |
| Trial ID | NCT05825105 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals over 35 years old with a radiological diagnosis of knee osteoarthritis and a WOMAC score of 24 or higher.
✕Probably not a fit
Patients with knee prostheses, rheumatoid arthritis, or other specified blood disorders will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of platelet-rich plasma (PRP) treatment for patients suffering from knee osteoarthritis (OA). It aims to compare two different methods of PRP application to determine which is more effective in reducing pain and improving joint function. Participants will be assessed using the WOMAC scale and other measures to gauge their response to the treatment. The study seeks to optimize PRP preparation and identify patient characteristics that may influence treatment outcomes.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce pain and improve mobility for patients with knee osteoarthritis.
How similar studies have gone: Previous studies have shown promising results with platelet-rich plasma treatments for osteoarthritis, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Radiological diagnosis of knee OA * Age over 35 years old * WOMAC value of 24 or higher at the time of recruitment Exclusion Criteria: * Patients with knee prosthesis, rheumatoid arthritis, contralateral lower limb amputation, any type of blood dyscrasia, hypofibrinogenemia, depot pool syndrome, or any other form of thrombocytopathy or chronic leukocytosis will be excluded from the study. * Patients with anticoagulant or acute coagulopathies, as well as carriers of any infectious disease or superficial infection at the puncture site, will be temporarily excluded from the study until their clinical recovery is confirmed by laboratory testing.
Where it's running
-
Institute for Research and Development in Bioengineering and Bioinformatics (IBB-CONICET-UNER)
Oro Verde, Entre Ríos, Argentina Recruiting
Study contacts
- Study coordinator: Pablo Schierloh, PhD
- Email: pablo.schierloh@uner.edu.ar
- Phone: +5491131325656
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Effects of virtual reality on walking in adults with knee osteoarthritis
This study tests how immersive virtual reality environments—designed to feel safe or to provoke fear—affect walking and worry about movement in adults 50 and older with knee osteoarthritis and in healthy peers.
-
Weekly berobenatide for knee osteoarthritis in adults who are overweight or obese
This study tests whether weekly berobenatide helps reduce knee pain and improve function, while also affecting body weight, in adults with knee osteoarthritis who are overweight or obese (with or without type 2 diabetes).
-
Autologous adipose-derived stem cell injections for knee osteoarthritis
We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.
-
Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.
-
Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status
Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.
-
Lysyl Enzymes in Knee Osteoarthritis
This study tests whether blood levels of lysyl hydroxylase and lysyl oxidase differ between people with knee osteoarthritis and healthy individuals.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.