Using PET imaging to study neuroinflammation in depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between neuroinflammation and glucose metabolism in patients with depression using advanced PET imaging techniques. It employs two tracers, [18F] DPA-714 and [18F] FDG, to visualize metabolic and neuroinflammatory changes in the brain. The research aims to identify differences in microglial activation and glucose metabolism in specific brain regions between individuals with recurrent and first-episode depression compared to a control group. By understanding these mechanisms, the study hopes to shed light on the pathogenesis of depression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. For all groups :

   * No alcohol or psychoactive substances such as coffee had been consumed in the 24 hours prior to the examination
   * MMSE≥24 points，MOCA≥26 points
   * No anti-infective drugs in the past 1 month, no cold, fever or other infection history in the past 2 weeks
   * Patients with diabetes had fasting controlled below 9.0mmol/L before the examination
   * Volunteer to participate in the study and sign the informed consent
2. For Recurrent depression patients:

   * Meet the Diagnostic criteria for recurrent major depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)
   * Age 35-85 years old, gender is not limited
   * HAMD≥8 points
3. For first episode depression Patients:

   * Gender, age and education level were matched with the recurrent depression group
   * Meet the Diagnostic criteria for the first episode of depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)
   * HAMD≥8 points
4. For controls:

   * Healthy people undergoing "DPA-714 or FDG imaging PET/MRI" physical examination in PET/CT room of our hospital
   * Gender and education level were consistent with both the recurrent depression group and the first-episode depression group
   * never used any psychotropic drugs
   * HAMD\<8 points；HAMA\<7 points

Exclusion Criteria(for all groups):

* Have a history of organic mental disorders or other mental disorders
* A family history of hereditary diseases
* Persons with mental retardation or dementia
* A history of psychoactive substance abuse
* Can not cooperate with/complete the psychological examination scale
* Previously found serious physical diseases (heart, brain, liver, lung and kidney)
* MRI contraindications, abnormalities found in head CT or MRI
* A history of drug or alcohol abuse
* Have a history of metabolic diseases such as hyperthyroidism, hypothyroidism,and rheumatic diseases
* are in the state of pregnancy or breastfeeding

Where it's running

• The First Affiliated Hospital of Dalian Medical University
  Dalian, Liaoning, China Recruiting

Study contacts

• Principal investigator: Huimin Zhang — The First Affiliated Hospital of Dalian Medical University
• Study coordinator: Huimin Zhang
• Email: huiminzhangxs@163.com
• Phone: +86 18098876233

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.