Using osteopathic manipulation to manage pain in sickle cell disease

Effects of Osteopathic Treatment in Combination With Usual Care in the Management of Pain Associated With Sickle Cell Disease: A Randomized Controlled Trial.

Not applicable Interventional College Osteopathique de Provence Aix-Marseille · NCT05632289

This study is testing if osteopathic manipulation can help people with sickle cell disease manage their pain better.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment37 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorCollege Osteopathique de Provence Aix-Marseille Academic / other
Locations1 site (Marseille, Paca)
Trial IDNCT05632289 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of osteopathic manipulative therapy in alleviating pain associated with sickle cell disease. Patients suffering from acute or chronic pain related to their condition will receive either osteopathic treatment or a sham treatment. The goal is to determine if the osteopathic approach can improve pain management and enhance the quality of life for these patients. The study aims to provide a complementary treatment option alongside standard pain management strategies.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 with major sickle cell syndrome experiencing acute or chronic pain.

Not a fit: Patients who are pregnant, have recently undergone surgery, or have specific medical contraindications to osteopathic manipulations will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce pain and improve the quality of life for patients with sickle cell disease.

How similar studies have performed: Previous studies have indicated that osteopathic approaches can be effective in managing chronic pain, suggesting potential success for this study.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients with major sickle cell syndrome
* Suffering from acute or chronic pain
* Aged over 18 and legally responsible
* The informed consent of the patients will be collected

Exclusion Criteria:

* Pregnant or breastfeeding women
* Patients who underwent surgery in the 6 months prior to inclusion
* Patients with known medical contraindications to osteopathic manipulations: vertebral compression, severe osteoporosis, progressive osteonecrosis and not treated with a prosthesis
* Patients with acute stroke
* Patients with cerebral arteriovenous malformation or cerebral aneurysm
* Patients participating in another interventional clinical research protocol

Where this trial is running

Marseille, Paca

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Sickle Cell Diseaseosteopathic manipulative treatmentsickle cell disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.