Using Optical Coherence Tomography to assess Uveitis
Official title: Objective Grading of Intraocular Inflammation in Uveitis Using Optical Coherence Tomography
Run by Oregon Health and Science University · NCT02026128 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how Optical Coherence Tomography can help doctors better understand and measure the severity of uveitis by looking at inflammatory cells in the eye.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Trial ID | NCT02026128 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with specific clinical features indicative of uveitis.
✕Probably not a fit
Patients unable to provide informed consent or maintain stable fixation for OCT imaging may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study utilizes Optical Coherence Tomography (OCT) to evaluate the severity of uveitis by measuring the presence of inflammatory cells in the anterior chamber of the eye. The study aims to standardize the grading of these cells and investigate differences in cell size and protein concentration across various uveitis diagnostic categories. Participants will undergo OCT testing alongside standard assessments like visual acuity and slit lamp exams to determine their eligibility based on specific clinical features of uveitis. Background data on participants' demographics and medical history will also be collected to support the findings.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and management of uveitis, enhancing patient outcomes.
How similar studies have gone: While the use of OCT in uveitis is a growing area of interest, this specific approach to standardizing cell grading is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age and older * With one or more of the following clinical features: 1. \>1+ AC cells; 2. \>1+ vitreous haze; 3. presence of vitreous cells; 4. presence of blood in anterior chamber; 5. presence of blood in vitreous; 6. presence of aqueous or vitreous pigment. * In one of the following diagnostic categories as determined by a uveitis specialists: 1. uveitis due to ankylosing spondylitis (positive HLA B27 genotype); 2. uveitis due to sarcoidosis; 3. uveitis of any additional type; 4. uveitis masquerade such as pigment dispersion syndrome or Schaffer's sign; 5. hyphema due to trauma or other causes; 6. vitreous hemorrhage; 7. retinal tear. Exclusion Criteria: * Inability to give informed consent; * Inability to maintain stable fixation for OCT imaging.
Where it's running
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Oregon Health & Science University
Portland, Oregon, United States Recruiting
Study contacts
- Principal investigator: David Huang, MD, PhD — Oregon Health and Science University
- Study coordinator: Denny Romfh, OD
- Email: romfhd@ohsu.edu
- Phone: 503-494-4351
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Ocular Fluid Work-up in Presumed Trematode-Induced Granulomatous Uveitis
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PANDA-ASOCT: Detecting Uveitis in Children with Automated Eye Image Analysis
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-
GenSci048 vs placebo in active non-infectious uveitis
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Uveitis in children under 18
This project collects medical information from children with uveitis to see how often different types occur and what treatments and clinical features look like.
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Metagenomic testing for infections in people with eye inflammation
This project will test metagenomic sequencing on eye fluid to find infections in adults with unexplained ocular inflammation who are at risk of vision loss.
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Observational study on chronic uveitis in children
This study is trying to gather information about chronic uveitis in children to improve how doctors diagnose and treat this rare eye condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.