Using optical biopsy to diagnose peritoneal nodules in colorectal cancer patients during surgery
Official title: Use of Probe-based Confocal Laser Endomicroscopy to Perform Optical Biopsy for Peritoneal Nodules in Colorectal Cancer Patients During Surgery
Run by Nanfang Hospital, Southern Medical University · NCT05879783 · Data updated 2026-11-12
This study is testing a new way to quickly check for cancer spread in the abdomen during surgery for colorectal cancer patients using a special imaging technique.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 278 (estimated) |
| Sponsor | Nanfang Hospital, Southern Medical University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | September 15, 2022 |
| Main results expected | September 15, 2023 |
| Study ends | December 15, 2027 |
| Registry record updated | August 23, 2023 |
| Trial ID | NCT05879783 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 to 85 with colorectal cancer who are scheduled for surgical treatment.
✕Probably not a fit
Patients who are pregnant, have severe liver damage, or significant renal insufficiency may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to improve the diagnosis of peritoneal metastasis in colorectal cancer patients by utilizing confocal laser endomicroscopy (pCLE) during surgical procedures. The approach allows for real-time, in vivo histological examination of suspected peritoneal nodules, potentially reducing the time taken for pathological confirmation. By using intravenous fluorescent agents, pCLE enhances the visibility of mucosal elements, facilitating an optical biopsy that can provide immediate diagnostic results. This method seeks to streamline the surgical process and improve patient outcomes by enabling quicker decision-making during surgery.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the time required for diagnosing peritoneal metastasis, leading to more timely surgical interventions.
How similar studies have gone: While the use of confocal laser endomicroscopy is a novel approach in this context, similar techniques have shown promise in other areas of cancer diagnosis.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age from over 18 to under 85 years 2. American Society of Anesthesiology (ASA) score class I,II,or III 3. Colorectal cancer 4. Patients who be about to undergo surgical treatment 5. Written informed consent Exclusion Criteria: 1. Pregnant or lactating women 2. Acute renal insufficiency or stage II to IV chronic renal insufficiency 3. Patients with severe liver damage 4. Asthma patients or patients with allergic constitution
Where it's running
-
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Jun Yan, M.D., Ph.D. — Nanfang Hospital, Southern Medical University
- Study coordinator: Jun Yan, M.D., Ph.D.
- Email: yanjunfudan@163.com
- Phone: 086-13825066546
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Knife-assisted full-thickness resection for rectal lesions in a multicenter setting
A multicenter study tests knife-assisted full-thickness resection (kFTR) to remove rectal lesions in adults and see how well it works and how safe it is.
-
Personalized 3D Bioprinted Colorectal Cancer Microenvironment Model
This study tests patient-derived, 3D-bioprinted cancer models that include tumor, fibroblast, and immune cells to see if they can better predict how colorectal cancer will respond to treatment.
-
Integrated genomic and clinical database for cancer biomarker discovery
Researchers are building a combined genomic and clinical database at Samsung Medical Center to test biomarkers for cancer diagnosis, treatment choice, and predicting how well treatments work.
-
Prehabilitation with Resistance, Aerobic, or Both Before Colorectal Surgery
Four pre-surgery exercise options (resistance, aerobic, both, or none) will be tested to see which best reduces complications after colorectal cancer surgery.
-
Liver transplantation for colorectal cancer with liver metastases
This study follows adults with stage IV colorectal cancer whose disease is limited to the liver and who are getting a liver transplant as part of their cancer care to see how they fare over time.
-
LTZ-232: a first-in-human test in advanced colorectal and other solid tumors
A first-in-human study tests LTZ-232, a new therapy for adults with unresectable or metastatic colorectal cancer and other solid tumors that have not responded to standard treatments.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.