Using Oliceridine for Pain Relief After Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify the optimal dosage of oliceridine for managing postoperative pain in patients undergoing upper abdominal laparoscopic surgery. It involves 80 elective patients who will be randomly assigned to receive different doses of oliceridine or morphine for pain management. The study will assess various outcomes, including pain relief, recovery speed, and potential side effects, while also exploring the molecular mechanisms behind oliceridine's effects through microbiomics and metabolomics. This innovative approach seeks to enhance postoperative recovery and broaden the understanding of oliceridine's clinical applications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ASA grades 1-2
2. Age \> 18 years and \< 70 years
3. Laparoscopic upper abdominal surgery under general anesthesia is planned, and the operation time is not more than 4 hours
4. Voluntarily receive postoperative controlled intravenous analgesia
5. Subjects understand and can cooperate with this study
6. Subjects can provide and sign written informed consent prior to conducting investigation-related screening procedures

Exclusion Criteria:

1. BMI\>30 kg/m2 or \< 19 kg/m2
2. Patients with preoperative use of opioids, acute and chronic pain or hyperalgesia
3. Patients with coronary atherosclerotic heart disease, significant ischemic heart disease, severe angina, heart failure, valvular disease or other heart disease
4. More severe hepatic and renal insufficiency
5. A history of mental illness or alcoholism
6. A history of alcohol or drug abuse
7. Combined with cranial pressure, intraocular pressure or glaucoma
8. Poorly controlled or untreated hypertension before surgery
9. Preeclampsia or eclampsia
10. Untreated and undertreated hyperthyroidism
11. Combined with autoimmune disease
12. Unable to use the numerical rating scale
13. History of chronic cough
14. Surgery is expected to take more than 4 hours Patients enrolled in other clinical trials within 3 months

Where it's running

• Tongji Hospital
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Hui Xu
• Email: huixu@tjh.tjmu.edu.cn
• Phone: +8613971001596

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.