Using neuro-navigated TMS to assess spinal cord injury outcomes
Neuro-navigated TMS for Chronic SCI Patients
This study is testing if a new brain stimulation technique can help better measure recovery in people with long-term spinal cord injuries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Sex | All |
| Sponsor | King's College Hospital NHS Trust Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06075056 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of neuro-navigated Transcranial Magnetic Stimulation (nTMS) as an additional outcome measure alongside established European Multicenter Study about SCI (EM-SCI) assessments in patients with chronic spinal cord injuries (SCI). The study will involve comparing nTMS results with EM-SCI assessments in two groups of ten patients each, one with chronic thoracic SCI and the other with chronic cervical SCI. The goal is to validate nTMS as a reliable assessment tool that could enhance the evaluation of functional outcomes in SCI clinical trials. This research is part of a broader initiative to develop regenerative therapies for SCI.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with chronic spinal cord injuries resulting from a single traumatic event at least six months prior to recruitment.
Not a fit: Patients with a history of malignancy, other neurological diseases, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new, reliable assessment method that enhances the evaluation of treatment outcomes for spinal cord injury patients.
How similar studies have performed: While the use of nTMS in this context is innovative, similar studies have shown promise in utilizing advanced assessment techniques for neurological conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Single traumatic event at least 6 months prior to recruitment * ISNCSCI grade A, B, C or D * Able to participate in EM-SCI and nTMS assessments and capable of informed consent Exclusion Criteria: * History of Malignancy * History of other Neurological disease * Pregnancy * Other cord lesions or tethering * Cord transaction or penetrating injury
Where this trial is running
London
- King's College Hospital — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Aminul Ahmed — King's College London
- Study coordinator: Azharul Khan
- Email: azharul.khan@nhs.net
- Phone: 07932554463
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.