Using nasal nitric oxide testing to improve diagnosis of primary ciliary dyskinesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect data on the effectiveness of nasal nitric oxide testing as a diagnostic tool for primary ciliary dyskinesia (PCD). Participants will be referred by pulmonary providers based on clinical symptoms suggestive of PCD. The study will enroll individuals aged 2 years and older who meet specific clinical criteria and provide informed consent. The goal is to enhance the diagnostic approach for PCD by gathering real-world data on this non-invasive testing method.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 2 years of age
* Must have two of the following clinical history points:
* Neonatal respiratory distress
* Chronic nasal congestion/runny nose
* Chronic cough
* Situs/laterality defects
* Bronchiectasis
* Ability to provide informed consent or consent of parent/guardian and ass

Exclusion Criteria:

* Recent history of sinus surgery or bloody nose in the past week
* Age \< 2 years of age
* Inability to tolerate probe in nose
* Sinusitis or other respiratory exacerbation currently being treated with antibiotics
* Admitted to hospital for respiratory exacerbation (inpatient status)
* Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by the IRB)
* Any other reason for which the study investigators feel the patient is not a good candidate to complete the testing

Where it's running

• Pulmonary Division
  Hartford, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Melanie S Collins, MD — Connecticut Children's Medical Center
• Study coordinator: Melanie S Collins, MD
• Email: mcollin@connecticutchildrens.org
• Phone: 860-545-9440

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.