Using muscadine wine to enhance brain health and mood
Acute and Chronic Impacts of Muscadine Wine Polyphenols on Cognition, Memory, Mood, and Anxiety in Adults Over 50 Years of Age
This study is testing whether drinking muscadine wine can help improve brain health and mood in healthy adults over 50.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 50 Years to 65 Years |
| Sex | All |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Trial ID | NCT05541887 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of muscadine wine polyphenols on cognitive performance, memory, and mood in healthy adults over 50 years old. The study aims to determine whether both acute and chronic intake of these polyphenols can improve mental health by regulating the hypothalamic-pituitary-adrenal (HPA) axis, reducing inflammation, and alleviating oxidative stress. Participants will be given either muscadine wine polyphenols or a placebo, and their cognitive functions will be assessed throughout the trial. This research seeks to provide the first clinical evidence of the impact of muscadine wine on brain health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults over the age of 50 with a BMI between 18.5 and 29.9.
Not a fit: Patients with clinically diagnosed mental illnesses, cardiovascular or neurological disorders, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new dietary interventions for improving cognitive health and mental well-being in older adults.
How similar studies have performed: While other studies have shown positive effects of polyphenol-rich foods on cognition and mood, this specific approach using muscadine wine polyphenols is novel and has not been previously tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy * BMI (18.5-29.9) * Body weight ≥110 pounds Exclusion Criteria: * Pregnancy * Breast-feeding * Smokers * Diabetic * Heavy drinkers * Subjective but not clinically diagnosed cognitive impairment (Montreal cognitive assessment score \<26), * Inability to understand the cognitive function tasks * Intake of medication that might influence the outcome of the study (e.g. psychostimulant) * cannabis product user * Clinically diagnosed mental illnesses * Cardiovascular and neurological disorders * Uncontrolled hypertension
Where this trial is running
Gainesville, Florida
- Food Science and human nutrition department at University of Florida — Gainesville, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Liwei Gu, PhD — University of Florida
- Study coordinator: Kylee Mai
- Email: cmai1@ufl.edu
- Phone: 479-203-8170
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.