Using MSOT to Diagnose and Monitor Neuromuscular Diseases in Children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of Multispectral Optoacoustic Tomography (MSOT) as a non-invasive biomarker for diagnosing and monitoring neuromuscular diseases (NMDs) in children. MSOT scans will be performed on muscle regions to assess hemo/myoglobin, collagen, lipid content, and oxygenation levels in patients with confirmed or suspected NMDs. The study will correlate MSOT data with existing clinical, laboratory, and imaging data from standard care procedures over a period of approximately 36 months, with repeated measurements to track disease progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients with neuromuscular disease

* Children (from birth (infants that are born term) to 18 years of age) participants or consent through authorized guardian
* Confirmed or suspected diagnosis of a neuromuscular disease (through molecular genetics, biopsy, clinical examination)

Exclusion Criteria:

Participants:

* Diagnosis is not consistent with a confirmed or suspected neuromuscular disease
* Patients with active skin lesions (e.g. infections, trauma) or confirmed genetic disorders (e.g. epidermolysis bullosa) that predisposes to skin lesion
* Medically unstable patients
* Tattoo on skin overlying the area to be examined
* Missing consent form
* Exclusion due to safety concerns of the investigator (subject who has any condition, including any physical, psychological, or psychiatric condition, which in the opinion of the Investigator, would compromise the safety of the subject or the quality of the data and renders the subject an unsuitable candidate for the study)
* Medication leading to increased light sensitivity

Where it's running

• Cheo
  Ottawa, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Hanns Lochmuller, Dr.
• Email: hlochmuller@toh.ca
• Phone: (613) 737-7600

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.