Using MRI to predict outcomes of deep brain stimulation in Parkinson's disease
Multimodal Magnetic Resonance Imaging Studying the Mechanism and Predicting the Outcome After Deep Brain Stimulation in Patients With Parkinson's Disease
This study is testing if MRI scans can help predict how well deep brain stimulation will work for people with advanced Parkinson's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | Chinese PLA General Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05003206 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of deep brain stimulation (DBS) for treating advanced Parkinson's disease by utilizing multimodal MRI techniques. It aims to clarify the mechanisms behind DBS in alleviating both motor and non-motor symptoms and to identify imaging indicators that can predict patient prognosis. Patients will undergo preoperative and postoperative MRI scans, alongside evaluations of their symptoms before and one year after the procedure. The study seeks to enhance individualized treatment approaches for Parkinson's disease based on MRI findings.
Who should consider this trial
Good fit: Ideal candidates include patients under 70 years old diagnosed with Parkinson's disease who are undergoing bilateral subthalamic nucleus deep brain stimulation.
Not a fit: Patients with Parkinson-plus syndrome, severe mental disorders, or other significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment strategies for patients with Parkinson's disease.
How similar studies have performed: Other studies have shown promise in using imaging techniques to guide treatment in neurological disorders, but this specific approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with Parkinson's disease * age\< 70 years * Underwent bilateral STN-DBS or not * Having complete medical history and clinical follow up * All MRI examination performed according to study protocol * Imaging data can be processed * Signed informed consent obtained from the patient or patient's legally authorized representative; Exclusion Criteria: * Parkinson-plus syndrome or secondary parkinsonism * Patients with severe mental disorders such as psychosis, liver and kidney dysfunction, poor blood pressure or blood glucose control, severe depression and substance abuse, low IQ, and acute phase of severe stroke with definite limb dysfunction should also be excluded.
Where this trial is running
Beijing, Beijing
- Chinese PLA General Hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Study coordinator: Yina Lan
- Email: lanyn1220@163.com
- Phone: +86-17326826301
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.