Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using MRI to improve cancer radiotherapy

Official title: Northern Alberta Linac-MR Image-Guided Human Clinical Trials - 1

Run by AHS Cancer Control Alberta · NCT04358913 · Data updated 2026-11-12

This study is testing if using special MRI scans can help doctors see tumors better during radiation treatment for adults with cancer.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment250 (estimated)
SponsorAHS Cancer Control Alberta
Academic / other
Drugs / interventionsradiation
Locations1 site (Edmonton, Alberta)
StatusRecruiting
StartedAugust 23, 2021
Main results expectedJanuary 2029
Study endsJanuary 2029
Registry record updatedNovember 3, 2026
Trial IDNCT04358913 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who are fit for high dose external beam radiation therapy.

Probably not a fit

Patients with contraindications for MRI or those unable to lie flat and still during the scan may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot phase clinical trial aims to optimize magnetic resonance imaging (MRI) sequences using the Alberta linac-MR P3 system for adult cancer patients undergoing high dose external beam radiotherapy. Participants will undergo a single MR imaging session lasting 30 to 40 minutes, with the potential for an optional sub-study involving five additional sessions to assess inter-fraction motion. The goal is to develop high-quality MR images that can enhance the visualization of tumors during treatment, ultimately improving patient outcomes in radiotherapy.

Why it matters

Potential benefit: If successful, this approach could lead to more accurate targeting of tumors during radiotherapy, potentially improving treatment effectiveness and reducing side effects.

How similar studies have gone: While the use of MRI in radiotherapy is an emerging field, similar studies have shown promise in improving treatment accuracy and patient outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults ≥ 18 years of age
* Patients deemed fit to undergo high dose external beam radiation therapy by their attending radiation oncologist

Exclusion Criteria:

* Patients with contraindications for MRI
* Patients who are unable to lie flat and still for the duration of the expected scan acquisition
* Patients who are unable to provide informed consent

Where it's running

  • Cross Cancer Institute
    Edmonton, Alberta, Canada
    Recruiting

Study contacts

  • Principal investigator: Nawaid Usmani, MD — Cross Cancer Institute, Alberta Health Services
  • Study coordinator: Nawaid Usmani, MD
  • Email: Nawaid.Usmani@ahs.ca
  • Phone: 780-432-8518

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.