Using MRI to evaluate brain health in patients with small vessel disease
Magnetic Resonance Imaging in Cerebral Small Vessel Disease
This study is testing if advanced MRI scans can help find early signs of brain changes in people with small vessel disease to improve their treatment and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese PLA General Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT05200377 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on cerebral small vessel disease (cSVD), which is a significant cause of ischemic strokes and vascular cognitive impairment. It aims to utilize advanced magnetic resonance imaging (MRI) technologies to detect early changes in brain structures and vascular functions associated with cSVD. By identifying these changes early, the study seeks to improve clinical outcomes through timely interventions. Participants will undergo MRI assessments to evaluate their brain health and cognitive function.
Who should consider this trial
Good fit: Ideal candidates are individuals with clinical or MRI evidence of cerebral small vessel disease who are cognitively intact and able to consent.
Not a fit: Patients with contraindications to MRI or those who cannot tolerate the procedure will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and better management of cerebral small vessel disease, potentially improving patient outcomes.
How similar studies have performed: Other studies have shown promise in using advanced MRI techniques for evaluating brain health, indicating that this approach is both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical evidence of cerebral small vessel disease or MRI evidence of lacunar infarcts and white matter hyperintensity * No disability (modified Rankin's scale \< 2) * No dementia (MMSE \> 24 and absence of dependence in daily activities) * Able and willing to consent Exclusion Criteria: * Contraindications to MRI * Standard MRI of bad quality due to movement artefacts * Pregnant * Unable to tolerate MRI
Where this trial is running
Beijing
- Chinese PLA General Hospital — Beijing, China (Recruiting)
Study contacts
- Principal investigator: Xin Lou, MD, PhD — Chinese PLA General Hospital
- Study coordinator: Kun Cheng, M.S.
- Email: dr_chengkun@163.com
- Phone: +8619921784434
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.