Using MRI to assess response to radiotherapy in soft tissue sarcoma
Neoadjuvant Radiotherapy of Soft Tissue Sarcomas of Limbs and Trunk : Interest of Multiparametric Quantitative MRI for Response Assessment and Per-treatment Progression Prediction
This study is testing how well radiotherapy works for people with soft tissue sarcoma in their arms or legs by using MRI scans before and after treatment to see how the tumor changes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Leon Berard Academic / other |
| Locations | 1 site (Lyon, Rhône) |
| Trial ID | NCT05684874 on ClinicalTrials.gov |
What this trial studies
This trial evaluates the effectiveness of neoadjuvant radiotherapy in patients with soft tissue sarcoma located in the limbs and trunk. Participants will undergo two multiparametric quantitative MRI scans: one before and one after the radiotherapy treatment. The study aims to analyze the changes in tumor characteristics as observed through these MRI scans, which will help in understanding the tumor's response to the treatment. A surgical resection will follow 6 to 8 weeks post-radiotherapy to further assess the tumor's characteristics.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a confirmed diagnosis of soft tissue sarcoma of the limbs or trunk who are eligible for neoadjuvant radiotherapy.
Not a fit: Patients with unresectable tumors, certain types of sarcomas like desmoid tumors, or those with multi-metastatic disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment strategies for soft tissue sarcoma by providing insights into tumor response to radiotherapy.
How similar studies have performed: While this approach is innovative, similar studies using MRI to assess treatment response in sarcomas have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA : * Patients 18 years of age or older; * Documented histologic diagnosis of soft tissue sarcoma of the limbs or trunk; * Validated indication for neoadjuvant radiotherapy, planned in the radiotherapy department of the Centre Léon Bérard; * No contraindication to Magnetic Resonance Imaging, * Signed informed consent; * Affiliation with a social security system or beneficiary of such a system. EXCLUSION CRITERIA : * Tumor considered as unresectable or patient considered as non-operable; * Desmoid tumor or dermatofibrosarcoma protuberans due to intermediate malignancy; * Rhabdomyosarcoma due to a different therapeutic management; * Multi-metastatic disease; * Pregnant or lactating woman, * Patient under guardianship, curatorship or deprived of liberty.
Where this trial is running
Lyon, Rhône
- Centre Léon Bérard — Lyon, Rhône, France (Recruiting)
Study contacts
- Principal investigator: Benoît ALLIGNET, MD — Centre Leon Berard
- Study coordinator: Benoît ALLIGNET, MD
- Email: benoit.allignet@lyon.unicancer.fr
- Phone: +33 4 78 78 59 06
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.