Using MRI to assess myelofibrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on developing and validating functional MRI parameters as biomarkers to analyze the extent of myelofibrosis and quantify treatment responses. Researchers will utilize diffusion MRI and T1-weighted imaging to evaluate water and fat content in bone marrow, aiming to identify changes that predict therapy effectiveness. The goal is to establish MRI techniques that can provide earlier insights into disease severity and treatment response compared to current clinical measures. This foundational research may pave the way for larger trials assessing existing and new therapies for myelofibrosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male /female subjects over the age of 18
2. Diagnosis of primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis.
3. No contraindications to MRI
4. Able to undergo MRI without anesthesia

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Exclusion Criteria:

1. Patients with pacemakers or other implanted magnetic devices that may malfunction or move because of the strong magnetic field inside the MRI room and scanner.
2. Any prior adverse event associated with MRI that is not related to injection of contrast agents or other medicines.

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Where it's running

• University of Michigan Hospital
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Gary Luker, M.D. — University of Michigan Hospital
• Study coordinator: Gary Luker, M.D.
• Email: gluker@umich.edu
• Phone: 734-763-5476

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Nelfinavir to improve anemia in people with myelofibrosis by restoring iron delivery to the bone marrow

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• National registry for people with myelofibrosis and anemia in Germany.

  This project will collect health, treatment, and quality-of-life information from people in Germany with primary or secondary myelofibrosis and anemia to see how their care and symptoms change over time.

  Recruiting iOMEDICO AG · Multiple Locations · NCT06976918

• Evaluating DISC-0974 for treating anemia in myelofibrosis patients

  This study tests if a new treatment called DISC-0974 can help people with myelofibrosis who have anemia feel better and improve their condition.

  Recruiting at 33 sites Phase 1/2 Disc Medicine, Inc · Gilbert, Arizona and 34 other locations · NCT05320198

• Elritercept vs. placebo for adults with myelofibrosis and anemia on ruxolitinib

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  Recruiting at 11 sites Phase 3 Takeda · Gilbert, Arizona and 213 other locations · NCT07623161

• TQ05105 tablets for intermediate/high-risk myelofibrosis

  This phase 2 study tests TQ05105 tablets to see if they help people with intermediate or high-risk myelofibrosis who have not benefited from prior JAK inhibitors.

  Recruiting at 24 sites Phase 2 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Hefei, Anhui and 23 other locations · NCT07551427

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.