Using modified high-flow nasal cannula therapy for patients with acute respiratory failure during bronchoscopy
Modified Nasal High-flow Oxygen Therapy for Acute Respiratory Failure Patients Undergoing Flexible Bronchoscopy
This study tests if a new way of using high-flow nasal cannula therapy can help patients with breathing problems during a bronchoscopy procedure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Chao Yang Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05759832 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the use of modified high-flow nasal cannula (HFNC) therapy for patients experiencing acute hypoxemic respiratory failure who require bronchoscopy. The study aims to optimize oxygenation and ventilation during the procedure by applying HFNC therapy through both nostrils, even as the bronchoscope occupies one of the nares. This approach seeks to prevent complications associated with traditional low-flow oxygen supplementation. The trial will assess the effectiveness of this modified therapy in improving patient outcomes during bronchoscopy.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who require bronchoscopy and have a PaO2/FiO2 ratio between 150 mmHg and 300 mmHg.
Not a fit: Patients who cannot tolerate HFNC therapy or require tracheal intubation will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance oxygenation and reduce complications for patients undergoing bronchoscopy with acute respiratory failure.
How similar studies have performed: While the use of HFNC therapy has shown promise in critically ill patients, this specific application during bronchoscopy is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years old; 2. Bronchoscopy is required; 3. 150 mmHg ≤ PaO2/FiO2 \< 300 mmHg. Exclusion Criteria: 1. Not tolerate HFNC oxygen therapy; 2. Obstruction of nasopharynx cavity; 3. Platelet\<60 × 109/L； 4. Need tracheal intubation; 5. The patient has received invasive ventilation.
Where this trial is running
Beijing, Beijing
- Beijing Chao-Yang Hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Study coordinator: Yu Zhao, Dr.
- Email: xuanben1985@163.com
- Phone: +8618601342030
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.