Using mitochondrial DNA in blood to monitor biliary tract cancer recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, observational study aims to evaluate the effectiveness of circulating tumor mitochondrial DNA (ct-mtDNA) in plasma as a biomarker for minimal residual disease (MRD) assessment and recurrence monitoring in patients with biliary tract cancer. Conducted at Tongji Hospital in Wuhan, the study will analyze plasma samples from patients with confirmed biliary tract cancer before and after treatment to detect mutations in mitochondrial DNA. The primary goal is to determine how MRD status impacts progression-free survival, while secondary objectives will explore the relationship between treatment and MRD markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologically confirmed biliary tract cancer (BTC);
* Expected survival time of 12 weeks or more;
* Signed informed consent form and ability to comply with the study visits and related procedures as stipulated in the protocol.

Exclusion Criteria:

* Patients with other active tumors or severe complications;
* Insufficient tumor tissue for MRD detection.

Where it's running

• Tongji Hospital
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Ze-yang Ding, M.D.
• Email: zyding@tjh.tjmu.edu.cn
• Phone: +8613407156200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.