Using metformin to enhance antidepressant treatment in obese patients with depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of metformin as an additional treatment for improving depressive symptoms in newly diagnosed obese patients already receiving standard antidepressant therapy. Participants will be randomly assigned to either a metformin group or a placebo group, with the primary outcome being the reduction in Hamilton Depression Rating Scale (HAM-D) scores. Secondary outcomes will assess oxidative stress markers through enzymatic activity measurements. The study aims to determine if metformin can significantly enhance the treatment of depression in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Age \>18 to \<45 years

  * Gender: Both genders (Male and Female)
  * BMI \>25
  * Diagnosis: Newly diagnose cases of depression (mild to severe)
  * HBA1C: Less than 5.7% (non-diabetic range)

Exclusion Criteria:

* Existing diabetes

  * Acute illnesses like acute kidney injury, recent history of myocardial infarction, acute liver injury
  * Intellectual disabilities or inability to understand due to any reason
  * Presence of Psychiatric disorders other than depression
  * Chronic kidney disease (eGFR \< 45 mL/min/1.73 m²).
  * Use of any psychotropic medication within the past 6 months.

Where it's running

• Fazaia Rurh Pfau Medical College
  Karachi, Sindh, Pakistan Recruiting
• Fazaia Ruth Pfau Medical College
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Principal investigator: sadia khan, MBBS — Fazaia Ruth Pfau Medical College
• Study coordinator: Sadia khan, MBBS
• Email: sadiakhansk30@gmail.com
• Phone: 0331359046

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.