Using metabolomics to predict treatment response in rectal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the metabolomic profiles of patients with locally advanced rectal cancer who are scheduled to receive total neoadjuvant therapy (TNT). By collecting blood, urine, tissue, and fecal samples at various stages of treatment, the study seeks to identify specific metabolites that can predict how well patients will respond to TNT and the likelihood of experiencing treatment-related toxicities, such as radiation proctitis. The goal is to enhance precision health by selecting patients who are most likely to benefit from TNT while minimizing complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologically confirmed adenocarcinoma of the rectum
* Scheduled to receive total neoadjuvant therapy

Exclusion Criteria:

* Previous pelvic radiation therapy
* Inflammatory bowel disease

Where it's running

• Linkou Chang Gung Memorial Hospital
  Guishan, Taoyuan, Taiwan Recruiting

Study contacts

• Study coordinator: Eric Yi-Liang Shen, PhD
• Email: pts@cgmh.org.tw
• Phone: 0975366392

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.