Using magnesium and ketamine to manage pain during hysteroscopy
Evaluating the Impacts of Intravenous Magnesium Sulfate and Ketamine on Cramping Pain and Total Opioid Consumption Following Hysteroscopy: A Prospective, Randomized Trial
This study is testing if magnesium and ketamine can help reduce pain for people having a hysteroscopy or D&C, compared to a placebo.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Corewell Health East Academic / other |
| Locations | 1 site (Royal Oak, Michigan) |
| Trial ID | NCT06745388 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of magnesium sulfate and ketamine in managing pain for patients undergoing elective hysteroscopy or dilation and curettage (D&C). Participants will be randomly assigned to receive either magnesium, ketamine, or a placebo, with both participants and evaluators blinded to the treatment assignments. The study aims to assess pain levels using the Visual Analog Scale at various intervals post-procedure and will monitor opioid consumption and adverse events for 24 hours following the surgery. The goal is to find safer alternatives to traditional opioid pain management.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled for an elective hysteroscopy or D&C and have an ASA Physical Status of 1 to 3.
Not a fit: Patients with chronic pain, psychiatric disorders, or those currently using certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a safer and more effective pain management option for patients undergoing hysteroscopy.
How similar studies have performed: Other studies have shown promising results using magnesium and ketamine for pain management, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing an elective hysteroscopy or dilation and curettage (D\&C) * American Society of Anesthesiologists (ASA) Physical Status 1 - 3 * Age 18 years or older Exclusion Criteria: * Chronic Pain Patients (taking opioids within one week of procedure) * Psychiatric Disorders (current treatment for anxiety/depression) * Allergies to any of the medications that will be administered * Current use of magnesium, analgesics, antidepressants, anxiolytics, or opioids * ASA Physical Status 4 or above * Developmentally delayed patients that would not be able to verbalize pain scores * Minors (under 18 years of age) * Pregnant women
Where this trial is running
Royal Oak, Michigan
- Corewell Health William Beaumont University Hospital — Royal Oak, Michigan, United States (Recruiting)
Study contacts
- Principal investigator: Ray Soto, MD — Corewell Health East
- Study coordinator: Ray Soto, MD
- Email: roy.soto@corewellhealth.org
- Phone: 248-898-0833
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.