Using magnesium and ketamine to manage pain during hysteroscopy
Official title: Evaluating the Impacts of Intravenous Magnesium Sulfate and Ketamine on Cramping Pain and Total Opioid Consumption Following Hysteroscopy: A Prospective, Randomized Trial
Run by Corewell Health East · NCT06745388 · Data updated 2026-11-12
This study is testing if magnesium and ketamine can help reduce pain for people having a hysteroscopy or D&C, compared to a placebo.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | Corewell Health East Academic / other |
| Locations | 1 site (Royal Oak, Michigan) |
| Status | Recruiting |
| Started | July 29, 2025 |
| Main results expected | September 2026 |
| Study ends | September 2026 |
| Registry record updated | August 20, 2025 |
| Trial ID | NCT06745388 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are scheduled for an elective hysteroscopy or D&C and have an ASA Physical Status of 1 to 3.
✕Probably not a fit
Patients with chronic pain, psychiatric disorders, or those currently using certain medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of magnesium sulfate and ketamine in managing pain for patients undergoing elective hysteroscopy or dilation and curettage (D&C). Participants will be randomly assigned to receive either magnesium, ketamine, or a placebo, with both participants and evaluators blinded to the treatment assignments. The study aims to assess pain levels using the Visual Analog Scale at various intervals post-procedure and will monitor opioid consumption and adverse events for 24 hours following the surgery. The goal is to find safer alternatives to traditional opioid pain management.
Why it matters
Potential benefit: If successful, this study could provide a safer and more effective pain management option for patients undergoing hysteroscopy.
How similar studies have gone: Other studies have shown promising results using magnesium and ketamine for pain management, suggesting this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing an elective hysteroscopy or dilation and curettage (D\&C) * American Society of Anesthesiologists (ASA) Physical Status 1 - 3 * Age 18 years or older Exclusion Criteria: * Chronic Pain Patients (taking opioids within one week of procedure) * Psychiatric Disorders (current treatment for anxiety/depression) * Allergies to any of the medications that will be administered * Current use of magnesium, analgesics, antidepressants, anxiolytics, or opioids * ASA Physical Status 4 or above * Developmentally delayed patients that would not be able to verbalize pain scores * Minors (under 18 years of age) * Pregnant women
Where it's running
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Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, United States Recruiting
Study contacts
- Principal investigator: Ray Soto, MD — Corewell Health East
- Study coordinator: Ray Soto, MD
- Email: roy.soto@corewellhealth.org
- Phone: 248-898-0833
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.