Using lung ultrasound to assess acute chest syndrome in children with sickle cell disease
Lung Ultrasound in Pediatric Acute Chest Syndrome
This study is testing if using lung ultrasound can help doctors better understand and treat acute chest syndrome in children with sickle cell disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 1 Month to 17 Years |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06497153 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on children aged 1 month to 17 years with sickle cell disease who are hospitalized for acute chest syndrome (ACS) at Robert-Debré Hospital. The research aims to identify pulmonary indicators that correlate with ventilation time and to explore the relationship between lung ultrasound (LUS) findings and the clinical severity of ACS. By utilizing bedside lung ultrasound, the study seeks to enhance the management of ACS through better categorization of lung involvement and tailored ventilatory strategies. The findings could lead to improved outcomes for pediatric patients suffering from this serious complication of sickle cell disease.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 1 month to 17 years with sickle cell disease who are hospitalized with suspected acute chest syndrome.
Not a fit: Patients who may not benefit from this study include those whose parents refuse participation or those who do not have social insurance.
Why it matters
Potential benefit: If successful, this study could lead to more effective management strategies for acute chest syndrome in children, potentially reducing ventilation time and improving patient outcomes.
How similar studies have performed: Other studies have shown promising results using lung ultrasound for diagnosing acute chest syndrome, indicating that this approach is gaining traction in pediatric care.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sickle cell disease patient aged 1 month to 17 years * Hospitalisation in the PICU of Robert-Debre hospital * Suspicion of acute chest syndrome ACS * No objection from a legal representative or the child taken in by the doctor. Exclusion Criteria: * Refusal of parents * Delay between first LUS and initiation of ventilator support greater than 6 hours * Patient without social insurance
Where this trial is running
Paris
- Robert Debré hOSPITAL — Paris, France (Recruiting)
Study contacts
- Principal investigator: Aurélie HAYOTTE, MD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Aurélie HAYOTTE, MD
- Email: aurelie.hayotte@aphp.fr
- Phone: +33.1.40.03.36.49
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.