Using lung ultrasound and Doppler to differentiate lung infections from atelectasis in ventilated patients
Role of Lung Ultrasound Imaging and Pulsed-wave Doppler in the Assessment of Lung Consolidations in Mechanically Ventilated Patients.
This study is testing if lung ultrasound and Doppler can help doctors tell the difference between lung infections and collapsed lungs in patients on ventilators to improve treatment and outcomes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre hospitalier de l'Université de Montréal (CHUM) Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Trial ID | NCT02100449 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of lung ultrasound and pulsed-wave Doppler in distinguishing between infectious lung consolidations and atelectasis in mechanically ventilated patients. It aims to improve the diagnostic accuracy for ventilator-associated pneumonia, which is often misdiagnosed using traditional chest radiography. By measuring regional acceleration time (RAcT) in pulmonary consolidations, the study seeks to provide a non-invasive and timely diagnostic tool that could expedite treatment initiation and potentially reduce mortality rates. The study will involve patients who are under mechanical ventilation and show signs of lung consolidations on imaging.
Who should consider this trial
Good fit: Ideal candidates for this study are mechanically ventilated patients presenting with one or more lung consolidations visible on chest imaging.
Not a fit: Patients who have contraindications to bronchoscopy or poor echogenicity due to factors like morbid obesity may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to faster and more accurate diagnoses of lung infections, improving patient outcomes in critically ill individuals.
How similar studies have performed: While the use of lung ultrasound in critical care is gaining traction, this specific approach combining Doppler measurements for differentiation has not been widely tested, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Under mechanical ventilation and presenting one or more consolidations on chest radiography or CT scan Exclusion Criteria: * Participation to another study * Poor echogenicity (morbid obesity, multiple thoracic dressings) * Contra-indications to superior limbs or torso mobilization * Contra-indications to bronchoscopy * Antibiotics initiated more than 24 hours but less than 72 hours before inclusion or changes in the antibiotic regimen in the last 72 hours.
Where this trial is running
Montreal, Quebec
- Centre Hospitalier de l'Université de Montréal (CHUM) — Montreal, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Martin Girard, MD, FRCPC — Centre hospitalier de l'Université de Montréal (CHUM)
- Study coordinator: Martin Girard, MD, FRCPC
- Email: martin.girard@umontreal.ca
- Phone: 514-890-8000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.