Using lung elastic power to predict ARDS severity and mortality in pneumonia patients

The Role of Elastic Power in Predicting the Severity and Mortality in Adult Patients With Acute Respiratory Distress Syndrome Secondary to Pneumonia

This study is testing if measuring lung elastic power can help predict how severe ARDS is and the chances of survival for adults with pneumonia who need mechanical ventilation.

Quick facts

• Study type: Observational
• Enrollment: 70 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: Benha University (Academic / other)
• Locations: 1 site (Banhā, Al Qalubeyah)
• Trial ID: NCT06477861 on ClinicalTrials.gov

What this trial studies

This observational study investigates the role of elastic power in predicting the severity and mortality of adult patients suffering from Acute Respiratory Distress Syndrome (ARDS) due to pneumonia. It aims to correlate the elastic power of the lungs with the severity index defined by the Berlin criteria, addressing limitations in current prognostic methods. The study will include patients aged 18 to 65 who meet the Berlin definition of ARDS and require mechanical ventilation for more than 48 hours. By analyzing various respiratory mechanics, the study seeks to improve the understanding of ARDS progression and patient outcomes.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 65 who meet the Berlin criteria for ARDS and require mechanical ventilation.

Not a fit: Patients outside the age range of 18 to 65 or those with ARDS not due to pneumonia may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance the ability to predict outcomes for ARDS patients, leading to better-targeted treatments.

How similar studies have performed: While there have been studies on ARDS, this specific approach using elastic power as a predictive measure is novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

Age from 18 to 65 years (male or female). Patients fulfilling criteria of ARDS as per Berline definition who will be admitted to ICU , intubated and MV more than 48 hours will be included in this study.

Fulfillment of Criteria of readiness for ARDS as per Berline definition :

1. an acute onset (\<1 week of a known clinical insult or new or worsening respiratory symptoms),
2. respiratory failure not primarily due to hydrostatic edema,
3. bilateral opacities on a chest radiograph (not fully explained by effusions, lobar or lung collapse, or nodules), and
4. \<300 mmHg of the ratio of arterial partial pressure of oxygen (PaO2) to the fraction of inspired oxygen (FiO2) (PaO2/FiO2) with 5 cm H2O of positive end-expiratory pressure (PEEP) or continuous positive airway pressure. To facilitate the estimation of the ARDS prognosis, the Berline definition classifies the severity of ARDS into 3 categories: mild (200 mmHg \< PaO2/FiO2 \< 300 mmHg), moderate (100 mm Hg \< PaO2/FiO2 \<200 mmHg), and severe (PaO2/FiO2 \< 100 mmHg).

Exclusion Criteria:

* Non intubated ICU admissions
* Non-invasive ventilated patients.
* Age less than 18 years or more than 65 years of age
* Open chest wall trauma.
* Patient requiring Extra Corporal Membrane Oxygenator
* Patients with increased intrabdominal pressure interfering with mechanical ventilator parameters measurements

Where this trial is running

Banhā, Al Qalubeyah

• Banha University Hospital — Banhā, Al Qalubeyah, Egypt (Recruiting)

Study contacts

• Study coordinator: Ahmed H Awad, MsC.ICU

Conditions Acute Respiratory Distress Syndrome