Using low oxygen levels during anesthesia to improve recovery after abdominal surgery
Goal-directed Low vs. High Oxygen Therapy During Anesthesia for Abdominal Surgery
This study is testing if using lower oxygen levels during anesthesia can help adults recover better from major abdominal surgery by improving their oxygen levels and lung function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Umeå University Academic / other |
| Locations | 1 site (Umeå) |
| Trial ID | NCT05263154 on ClinicalTrials.gov |
What this trial studies
This study investigates whether goal-directed low oxygen therapy during anesthesia can enhance oxygen levels and lung function in patients recovering from major abdominal surgery. A total of 200 adult patients will be randomly assigned to receive either low oxygen concentrations or fixed high oxygen concentrations during and after their surgical procedures. The primary outcome measured will be arterial oxygen partial pressure, while lung function will serve as a secondary outcome. The goal is to determine if tailored oxygen delivery can reduce postoperative hypoxia, a common complication following such surgeries.
Who should consider this trial
Good fit: Ideal candidates are adults scheduled for major abdominal cancer surgery lasting more than two hours and classified within American Society of Anesthesia Class 1-3.
Not a fit: Patients at risk for difficult intubation or those who decline participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative complications related to hypoxia in patients undergoing major abdominal surgery.
How similar studies have performed: Other studies have explored oxygen management during anesthesia, but this specific goal-directed approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being scheduled for a major abdominal cancer surgery lasting for more than 2 hours. * Having a condition within American Society of Anesthesia Class 1-3. Exclusion Criteria: * Being at risk for a difficult intubation during anesthesia in the form of Mallampati score 3-4, or having a previous documentation of difficult intubation. * Decline participation
Where this trial is running
Umeå
- University hospital — Umeå, Sweden (Recruiting)
Study contacts
- Principal investigator: Karl A Franklin, MD, PhD — Umeå University
- Study coordinator: Karl A Franklin, MD, Prof
- Email: karl.franklin@umu.se
- Phone: +46 907851256
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.