Using liquid biopsies to monitor treatment in HPV-related cancers
Official title: Liquid Biopsies - a Possible Tool for Treatment Monitoring and Early Recurrence Detection in HPV-associated Diseases
Run by The Institute of Molecular and Translational Medicine, Czech Republic · NCT05774561 · Data updated 2026-11-12
This study tests if using liquid biopsies can help track treatment progress and detect any return of HPV-related cancers, like cervical and throat cancer, in patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 480 (estimated) |
| Sponsor | The Institute of Molecular and Translational Medicine, Czech Republic Academic / other |
| Locations | 1 site (Olomouc) |
| Status | Recruiting |
| Started | June 1, 2022 |
| Main results expected | May 31, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT05774561 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include women diagnosed with cervical cancer or high-grade cervical intraepithelial lesions, and men and women diagnosed with oropharyngeal cancer.
✕Probably not a fit
Patients who do not have HPV-associated cancers or those who are not willing to participate in the study may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial evaluates the effectiveness of liquid biopsies for monitoring treatment in patients with HPV-associated cancers, including cervical cancer and oropharyngeal cancer. The study aims to identify sensitive and specific biomarkers that can help in early detection of disease recurrence. It involves both prospective and retrospective components, where fresh tumor tissues and archived samples will be analyzed. Regular liquid biopsy sampling will be conducted during follow-up to assess treatment response and recurrence risk.
Why it matters
Potential benefit: If successful, this approach could provide a non-invasive method for early detection of cancer recurrence, improving patient outcomes.
How similar studies have gone: Other studies have shown promise in using liquid biopsies for cancer monitoring, indicating a potential for success in this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Women diagnosed with CC/HSIL. Men and women diagnosed with OPC. Patients must agree with study enrollment and must sign study informed consent. Exclusion Criteria: No exclusion criteria are set.
Where it's running
-
University Hospital Olomouc
Olomouc, Czechia Recruiting
Study contacts
- Study coordinator: Marian Hajduch, MD., PhD.
- Email: marian.hajduch@upol.cz
- Phone: +420 585 632 083
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Self-sampling to improve cervical cancer screening attendance
This study is testing if sending self-sampling kits by mail, through gynecologists, or general practitioners can help more women in the Czech Republic get screened for cervical cancer.
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Blood test for detecting HPV-related gynecologic cancers
This study is testing a blood test that looks for HPV-related cancer DNA in women with serious cervical issues to see if it can help detect and monitor these cancers without needing invasive procedures.
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This study is testing if screening for anal cancer with Pap smears can help women over 40 who have vulvar lesions catch any problems early and improve their health.
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Cervical screening and care options for women living with HIV who test positive for high-risk HPV
This study tests different ways to screen and manage high-risk HPV in women with HIV to see what might work best for them.
-
Lived experiences of women with HPV infection
This study talks with women who have HPV to hear in their own words how the infection affects daily life, relationships, and what information or support they wish they had.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.