Clinical trial Recruiting at 1 site Observational Ages 18 to 99

Using liquid biopsies to monitor treatment in HPV-related cancers

Official title: Liquid Biopsies - a Possible Tool for Treatment Monitoring and Early Recurrence Detection in HPV-associated Diseases

Run by The Institute of Molecular and Translational Medicine, Czech Republic · NCT05774561 · Data updated 2026-11-12

This study tests if using liquid biopsies can help track treatment progress and detect any return of HPV-related cancers, like cervical and throat cancer, in patients.

More Cervical Cancer trials

Quick facts

Study typeObservational
Ages18 Years to 99 Years
SexAll
Enrollment480 (estimated)
SponsorThe Institute of Molecular and Translational Medicine, Czech Republic
Academic / other
Locations1 site (Olomouc)
StatusRecruiting
StartedJune 1, 2022
Main results expectedMay 31, 2027
Study endsDecember 1, 2027
Registry record updatedNovember 5, 2026
Trial IDNCT05774561 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include women diagnosed with cervical cancer or high-grade cervical intraepithelial lesions, and men and women diagnosed with oropharyngeal cancer.

Probably not a fit

Patients who do not have HPV-associated cancers or those who are not willing to participate in the study may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness of liquid biopsies for monitoring treatment in patients with HPV-associated cancers, including cervical cancer and oropharyngeal cancer. The study aims to identify sensitive and specific biomarkers that can help in early detection of disease recurrence. It involves both prospective and retrospective components, where fresh tumor tissues and archived samples will be analyzed. Regular liquid biopsy sampling will be conducted during follow-up to assess treatment response and recurrence risk.

Why it matters

Potential benefit: If successful, this approach could provide a non-invasive method for early detection of cancer recurrence, improving patient outcomes.

How similar studies have gone: Other studies have shown promise in using liquid biopsies for cancer monitoring, indicating a potential for success in this novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Women diagnosed with CC/HSIL. Men and women diagnosed with OPC. Patients must agree with study enrollment and must sign study informed consent.

Exclusion Criteria:

No exclusion criteria are set.

Where it's running

  • University Hospital Olomouc
    Olomouc, Czechia
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.