Using LINC01844 to Diagnose Cognitive Issues in Elderly Surgery Patients
Clinical Study on LINC01844 as a Diagnostic Marker for Early Postoperative Cognitive Dysfunction in Elderly Patients
This study is testing whether different types of anesthesia affect thinking skills after surgery in older patients and if a specific blood marker can help diagnose any cognitive problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 86 (estimated) |
| Ages | 65 Years to 85 Years |
| Sex | All |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT06387836 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of different inhalation anesthetics on postoperative cognitive dysfunction (POCD) in elderly patients undergoing elective lumbar decompression and fusion. It aims to compare the cognitive effects of isoflurane and desflurane while also assessing the diagnostic performance of the long intergenic non-coding RNA (LINC01844) levels in blood. Participants will undergo neuropsychological evaluations before surgery and on the 1st, 3rd, and 5th days post-surgery, alongside blood tests for LINC01844. The study is conducted at Zhongshan Hospital Fudan University in Shanghai, China.
Who should consider this trial
Good fit: Ideal candidates are elderly patients aged 65-85 scheduled for elective lumbar decompression and fusion surgery.
Not a fit: Patients with pre-existing cognitive dysfunction or significant sensory impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods for POCD, enhancing postoperative care for elderly patients.
How similar studies have performed: While the approach of using LINC01844 as a biomarker is novel, similar studies have shown promise in identifying cognitive dysfunction post-surgery.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled to perform elective lumbar decompression and interbody fusion under general anesthesia; * 65-85 years old; * American Society of Anesthesiologists (ASA) physical status I-III level; * Body mass index (BMI) between 20 Kg/m2 and 28 Kg/m2; * From whom written informed consent is obtainable either from the patient or from a legal representative; Exclusion Criteria: * Patents with cognitive dysfunction preoperatively; * Patents with verbal, visual and auditory defects; * Patients with history of alcohol and/or drug abuse, or history of neurological and psychotic disorders; * Patients with history of hospital admission and therapy within 30 days.
Where this trial is running
Shanghai, Shanghai
- Zhongshan Hospital Fudan University — Shanghai, Shanghai, China (Recruiting)
Study contacts
- Principal investigator: Shengjin Ge, Ph.D. — Fudan University
- Study coordinator: Danfeng Jin, M.D.
- Email: jindanfeng0506@163.com
- Phone: +8613795306154
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.