Using light therapy to treat precancerous cervical and vaginal lesions
Official title: Efficacy and Safety of Photodynamic Therapy for Cervical and Vaginal Intraepithelial Neoplasia:A Multicenter Prospective Cohort Study
Run by Peking University Third Hospital · NCT06982976 · Data updated 2026-11-12
This study is testing if light therapy can safely treat precancerous cervical and vaginal lesions in women with specific types of abnormal cells.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 250 (estimated) |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | February 28, 2025 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | May 21, 2025 |
| Trial ID | NCT06982976 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women diagnosed with high-grade squamous intraepithelial lesions or persistent low-grade lesions who are willing to receive treatment.
✕Probably not a fit
Patients with confirmed cancer, severe medical comorbidities, or allergies to light therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the efficacy and safety of photodynamic therapy using 20% 5-amino-ketovalerate and 630nm red light for treating cervical and vaginal intraepithelial neoplasia in women. The approach focuses on patients with confirmed high-grade squamous intraepithelial lesions or persistent low-grade lesions who are willing to undergo treatment. The study aims to gather real-world data on the treatment's effectiveness and safety profile.
Why it matters
Potential benefit: If successful, this treatment could provide a non-invasive option for women with precancerous cervical and vaginal lesions, potentially reducing the need for more invasive procedures.
How similar studies have gone: While photodynamic therapy has been explored in various contexts, this specific application for cervical and vaginal intraepithelial neoplasia is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * cervical/vaginal high-grade squamous intraepithelial lesions (HSILs) confirmed by colposcopy and pathological biopsy (CIN2 /CIN3 and/or VaIN2/ VaIN3) or persistent CIN1/VaIN1 lasting for more than one year with a strong willingness to treat; * colposcopy was adequate, and analysable colposcopy images were retained; * endocervical curettage (ECC) did not suggest higher-grade lesions. Exclusion Criteria: * coexistence or suspicion of cancer; * porphyria or suspected allergies to red and blue light; * severe medical comorbidities；
Where it's running
-
Peking Unniversity Third Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Qin Han
- Email: Lmlfe_lyn@126.com
- Phone: 13810632686
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Photodynamic therapy with 20% 5‑amino‑ketovalerate and 630 nm red light for CIN3
This will test whether photodynamic therapy using 20% 5‑amino‑ketovalerate plus 630 nm red light can clear CIN3 lesions in women.
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Evaluating PreveCol for Early Detection of Colorectal Cancer
This study is testing a new blood test called PreveCol to see if it can help find colorectal cancer and advanced polyps in people aged 50-69 who have already had a positive stool test.
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Investigating the role of extracellular DNA in gastric cancer development
This study is trying to see how changes in a type of DNA found outside of cells might affect the development of gastric cancer in patients with precancerous lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.