Using L-PRF in periodontal surgery to improve healing
The Effect of Application of L-PRF in Periodontal Surgery on Clinical Parameters and Patient Related Outcome Measures: A Randomized, Controlled, Clinical Study.
This study tests if adding a special treatment called L-PRF to a common gum surgery can help people heal better and feel less pain compared to just the surgery alone.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Ages | 18 Years to 89 Years |
| Sex | All |
| Sponsor | The University of Texas Health Science Center at San Antonio Academic / other |
| Locations | 1 site (San Antonio, Texas) |
| Trial ID | NCT06296498 on ClinicalTrials.gov |
What this trial studies
This study compares the outcomes of two procedures for treating periodontal disease: open flap debridement (OFD) alone and OFD combined with leukocyte and platelet-rich fibrin (L-PRF). Patients will be randomly assigned to receive one of the two treatments in a split-mouth design, allowing each participant to serve as their own control. The primary focus is on clinical outcomes and postoperative pain perception. The goal is to determine if the addition of L-PRF enhances wound healing and bone regeneration compared to standard care.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 89 who require open flap debridement for periodontal disease and meet specific smoking criteria.
Not a fit: Patients who smoke more than 10 cigarettes per day or are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved healing and reduced pain for patients undergoing periodontal surgery.
How similar studies have performed: Previous studies have shown promising results with the use of L-PRF in various surgical applications, suggesting potential benefits in periodontal procedures as well.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients between age 18 and 89 * Patients needing open flap debridement procedures for periodontal disease in one or more teeth in the same arch bilaterally (split mouth) * Patients must be nonsmokers, former smokers, or current smokers who smoke \<10 cigarettes per day, by self-report * Female patients to include non- pregnant women of child-bearing potential. Exclusion Criteria: * Patients who disclose that they will not be able to cooperate with the follow-up schedule. * Patients who are mentally incompetent, prisoners, or pregnant (as obtained via chart review or self-report) * Pregnant women or women intending to become pregnant during the study period * Smokers who smoke \> 10 cigarettes per day
Where this trial is running
San Antonio, Texas
- The University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Charles Powell, DDS, MS — The University of Texas Health Science Center at San Antonio
- Study coordinator: Charles Powell, DDS, MS
- Email: powellc2@uthscsa.edu
- Phone: 210-567-3593
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.