Using L-PRF in periodontal surgery to improve healing
Official title: The Effect of Application of L-PRF in Periodontal Surgery on Clinical Parameters and Patient Related Outcome Measures: A Randomized, Controlled, Clinical Study.
Run by The University of Texas Health Science Center at San Antonio · NCT06296498 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests if adding a special treatment called L-PRF to a common gum surgery can help people heal better and feel less pain compared to just the surgery alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 89 Years |
| Sex | All |
| Enrollment | 32 (estimated) |
| Sponsor | The University of Texas Health Science Center at San Antonio Academic / other |
| Locations | 1 site (San Antonio, Texas) |
| Trial ID | NCT06296498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 89 who require open flap debridement for periodontal disease and meet specific smoking criteria.
✕Probably not a fit
Patients who smoke more than 10 cigarettes per day or are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the outcomes of two procedures for treating periodontal disease: open flap debridement (OFD) alone and OFD combined with leukocyte and platelet-rich fibrin (L-PRF). Patients will be randomly assigned to receive one of the two treatments in a split-mouth design, allowing each participant to serve as their own control. The primary focus is on clinical outcomes and postoperative pain perception. The goal is to determine if the addition of L-PRF enhances wound healing and bone regeneration compared to standard care.
Why it matters
Potential benefit: If successful, this approach could lead to improved healing and reduced pain for patients undergoing periodontal surgery.
How similar studies have gone: Previous studies have shown promising results with the use of L-PRF in various surgical applications, suggesting potential benefits in periodontal procedures as well.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients between age 18 and 89 * Patients needing open flap debridement procedures for periodontal disease in one or more teeth in the same arch bilaterally (split mouth) * Patients must be nonsmokers, former smokers, or current smokers who smoke \<10 cigarettes per day, by self-report * Female patients to include non- pregnant women of child-bearing potential. Exclusion Criteria: * Patients who disclose that they will not be able to cooperate with the follow-up schedule. * Patients who are mentally incompetent, prisoners, or pregnant (as obtained via chart review or self-report) * Pregnant women or women intending to become pregnant during the study period * Smokers who smoke \> 10 cigarettes per day
Where it's running
-
The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States Recruiting
Study contacts
- Principal investigator: Charles Powell, DDS, MS — The University of Texas Health Science Center at San Antonio
- Study coordinator: Charles Powell, DDS, MS
- Email: powellc2@uthscsa.edu
- Phone: 210-567-3593
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.