Using ketone supplements to manage salt intake effects in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of ketone bodies, specifically β-hydroxybutyrate, on older adults who consume high levels of dietary salt. It aims to understand whether increasing β-OHB can mitigate the negative cardiovascular effects associated with high salt intake, particularly in relation to blood pressure and inflammation. Participants aged 50-85 will be assigned to different dietary interventions involving varying levels of salt and β-OHB to assess their effects on cardiovascular health. The study seeks to fill a critical gap in knowledge regarding dietary strategies to combat hypertension and cardiovascular disease in older populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between the ages of 60-85
* Resting blood pressure no higher than 150/90
* BMI below 35 kg/m2 (or otherwise healthy)
* Free of any metabolic disease (diabetes or renal), pulmonary disorders (COPD, severe asthma, or cystic fibrosis), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular)
* Do not have any precluding medical conditions that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners)

Exclusion Criteria:

* High blood pressure - greater than150/90 mmHg
* Obesity (BMI \> 30 kg/m2)
* History of metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD, severe asthma, \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
* Medical issues that prevent safe exercise (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis)
* Medical issues that prevent giving blood (e.g., blood thinners).
* Current smoking, using smokeless tobacco, or vaping (within past 12 months)
* Current pregnancy

Where it's running

• School of Public Health
  Bloomington, Indiana, United States Recruiting

Study contacts

• Study coordinator: Austin T Robinson, PhD
• Email: ausrobin@iu.edu
• Phone: 5745141034

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.