Using ketone supplements to manage salt intake effects in older adults
Ketone Supplementation as a Strategy to Reduce the Negative Health Effects of High Dietary Salt in Older Adults
This study is testing if ketone supplements can help older adults manage the harmful effects of a high-salt diet on their heart health and blood pressure.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Sponsor | Indiana University Academic / other |
| Locations | 1 site (Bloomington, Indiana) |
| Trial ID | NCT06868719 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of ketone bodies, specifically β-hydroxybutyrate, on older adults who consume high levels of dietary salt. It aims to understand whether increasing β-OHB can mitigate the negative cardiovascular effects associated with high salt intake, particularly in relation to blood pressure and inflammation. Participants aged 50-85 will be assigned to different dietary interventions involving varying levels of salt and β-OHB to assess their effects on cardiovascular health. The study seeks to fill a critical gap in knowledge regarding dietary strategies to combat hypertension and cardiovascular disease in older populations.
Who should consider this trial
Good fit: Ideal candidates for this study are older adults aged 50-85 with controlled blood pressure and no significant metabolic or cardiovascular diseases.
Not a fit: Patients with uncontrolled high blood pressure, obesity, or a history of cardiovascular disease are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a novel dietary strategy to help manage blood pressure and reduce cardiovascular disease risk in older adults.
How similar studies have performed: While there is limited evidence on the use of ketones in this specific context, previous studies have shown potential benefits of ketone bodies in metabolic health, indicating a promising area of investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Between the ages of 60-85 * Resting blood pressure no higher than 150/90 * BMI below 35 kg/m2 (or otherwise healthy) * Free of any metabolic disease (diabetes or renal), pulmonary disorders (COPD, severe asthma, or cystic fibrosis), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular) * Do not have any precluding medical conditions that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners) Exclusion Criteria: * High blood pressure - greater than150/90 mmHg * Obesity (BMI \> 30 kg/m2) * History of metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD, severe asthma, \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular). * Medical issues that prevent safe exercise (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) * Medical issues that prevent giving blood (e.g., blood thinners). * Current smoking, using smokeless tobacco, or vaping (within past 12 months) * Current pregnancy
Where this trial is running
Bloomington, Indiana
- School of Public Health — Bloomington, Indiana, United States (Recruiting)
Study contacts
- Study coordinator: Austin T Robinson, PhD
- Email: ausrobin@iu.edu
- Phone: 5745141034
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.