Using ketamine to reduce postoperative pain after bariatric surgery
Efficacy of Preventive Ketamine on Postoperative Pain: A Randomized, Double-blind Trial of Patients Undergoing Laparoscopic Sleeve Gastrectomy
This study tests whether giving ketamine along with a pain medication can help people feel less pain after having weight loss surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT04908579 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of preventive ketamine administration in combination with bupivacaine for managing postoperative pain in patients undergoing laparoscopic sleeve gastrectomy. The approach involves administering bupivacaine intraperitoneally along with ketamine either intraperitoneally or intravenously to optimize analgesia and improve patient comfort. The study aims to assess the impact of these interventions on postoperative pain, nausea, and vomiting, leveraging ketamine's established analgesic properties.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 to 60 with a body mass index between 35 and 60 who have well-controlled comorbidities.
Not a fit: Patients with a BMI over 60, severe systemic diseases, or those on certain psychiatric medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance pain management and recovery for patients undergoing bariatric surgery.
How similar studies have performed: Previous studies have shown positive outcomes with ketamine in pain management, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \- Body mass index \> 35 and \< 60 kg/m2 * Either medically free or with well controlled hypertension and/or diabetes. Exclusion Criteria: * \- Patient's refusal to participate in the study * BMI \> 60 kg/m2. * Age less than 21 years. * Patients with severe systemic disease which is not life-threatening. * Patients on antipsychotics, antidepressants and/or corticosteroids. * Patients with history of obstructive sleep apnea. * Allergic reaction to any of the study medications.
Where this trial is running
Cairo
- Ain-Shams University Hospitals — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Ibrahim Mamdouh Esmat
- Email: ibrahim_mamdouh@med.asu.edu.eg
- Phone: 01001241928
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.