Using ketamine to reduce pain during minor procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of intranasal ketamine as a supplement to local anesthesia for pain management during minor procedures in the emergency department. Participants, aged 7 to under 70, will be randomly assigned to receive either ketamine or a saline placebo alongside standard local anesthesia. The primary goal is to compare pain scores between the two groups using a numerical rating scale, while secondary outcomes will assess agitation in adults and alertness in children. This approach aims to improve patient comfort and procedural experiences in the ED.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Undergoing Minor Procedure in the ED
* Weight not to exceed 115kg

Exclusion Criteria:

* Altered Mental Status
* Pregnancy
* Breastfeeding
* Acute head or eye injury
* Intercranial Hypertension
* Hx of seizures
* Hx of chronic pain
* Unstable vital signs
* Allergy to Ketamine
* Hepatic or Renal Insufficiency
* Hx of Psychiatric Illness
* Hx of alcohol/drug abuse

Where it's running

• Loyola University Medical Center
  Maywood, Illinois, United States Recruiting

Study contacts

• Principal investigator: Trent Reed, DO — Loyola University
• Study coordinator: Shannon Lovett, MD
• Email: slovett@lumc.edu
• Phone: 708-327-2549

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TENS to Reduce Pain During Transperineal Prostate Biopsy

  This trial tests whether adding TENS to local anesthesia can lessen pain for men undergoing a transperineal prostate biopsy.

  Recruiting Medical University of Gdansk · Gdansk, Pomeranian Voivodeship · NCT07578324

• Sedation and pain control for adults with fractures and dislocations in the emergency department

  This project will try different sedation and pain-control methods to see which gives adults the best pain relief and satisfaction during emergency-room reductions of fractures or dislocations.

  Recruiting at 3 sites Region Zealand · Holbæk, Region Sjælland and 2 other locations · NCT07314450

• Effects of suctioning on pain and stress in intubated ICU patients

  This study is testing if suctioning the breathing tube in ICU patients causes more pain and stress compared to not suctioning.

  Recruiting Loma Linda University · Loma Linda, California · NCT06692400

• Examining pain relief mechanisms after lumbar nerve blocks

  This study is testing how well lumbar nerve blocks can relieve chronic low back pain and how the body's nervous system affects that relief in patients who are about to receive the treatment.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05961800

• Comparing pain perception with fast and slow tenaculum application techniques

  This study is testing whether placing a tenaculum slowly on the cervix causes less pain than doing it quickly for women undergoing this procedure.

  Recruiting Women and Infants Hospital of Rhode Island · Providence, Rhode Island · NCT05458037

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.