Using ketamine to reduce pain during minor procedures
Intranasal Ketamine as a Supplement to Local Anesthesia to Reduce Pain Associated With Minor Procedures in the Emergency Department
This study is testing if using a nasal spray of ketamine can help reduce pain during minor procedures in the emergency department for people aged 7 to under 70.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 108 (estimated) |
| Ages | 7 Years to 70 Years |
| Sex | All |
| Sponsor | Loyola University Academic / other |
| Locations | 1 site (Maywood, Illinois) |
| Trial ID | NCT06284473 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of intranasal ketamine as a supplement to local anesthesia for pain management during minor procedures in the emergency department. Participants, aged 7 to under 70, will be randomly assigned to receive either ketamine or a saline placebo alongside standard local anesthesia. The primary goal is to compare pain scores between the two groups using a numerical rating scale, while secondary outcomes will assess agitation in adults and alertness in children. This approach aims to improve patient comfort and procedural experiences in the ED.
Who should consider this trial
Good fit: Ideal candidates include adults and children aged 7 to less than 70 who are undergoing minor procedures in the emergency department.
Not a fit: Patients with altered mental status, pregnancy, or a history of psychiatric illness may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective pain management option for patients undergoing minor procedures.
How similar studies have performed: Previous studies have shown that sub-dissociative doses of ketamine can effectively manage pain, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing Minor Procedure in the ED * Weight not to exceed 115kg Exclusion Criteria: * Altered Mental Status * Pregnancy * Breastfeeding * Acute head or eye injury * Intercranial Hypertension * Hx of seizures * Hx of chronic pain * Unstable vital signs * Allergy to Ketamine * Hepatic or Renal Insufficiency * Hx of Psychiatric Illness * Hx of alcohol/drug abuse
Where this trial is running
Maywood, Illinois
- Loyola University Medical Center — Maywood, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Trent Reed, DO — Loyola University
- Study coordinator: Shannon Lovett, MD
- Email: slovett@lumc.edu
- Phone: 708-327-2549
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.