Using IPACK block to manage pain after ACL reconstruction

The Effect of IPACK Nerve Blocks on Early ACL Pain Scores

Phase 4 Interventional Loyola University · NCT05985629

This study is testing if an anesthetic technique called the IPACK block can help people feel less pain and use fewer pain medications after ACL reconstruction surgery.

Quick facts

PhasePhase 4
Study typeInterventional
Enrollment78 (estimated)
Ages16 Years and up
SexAll
SponsorLoyola University Academic / other
Locations1 site (Maywood, Illinois)
Trial IDNCT05985629 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of the IPACK block, an anesthetic technique, in controlling postoperative pain following ACL reconstruction surgery. Participants will be randomly assigned to receive either the IPACK block or a placebo before their surgery. Pain levels will be assessed using a visual analogue scale at multiple time points, and opioid consumption will be monitored to evaluate the need for pain relief medication. The study aims to determine if the IPACK block can reduce pain and opioid use in the immediate postoperative period.

Who should consider this trial

Good fit: Ideal candidates are patients aged 16 and older who are electing to undergo ACL reconstruction surgery and can provide informed consent.

Not a fit: Patients with previous knee surgeries, chronic opioid use, or allergies to local anesthetics may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved pain management and reduced reliance on opioids after ACL surgery.

How similar studies have performed: Other studies have shown promising results with similar anesthetic techniques, suggesting potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All patients presenting to Dr. John Miller with the Department of Orthopedic Surgery, Sports Medicine Division, at Loyola University Medical Center electing to undergo ACL reconstruction surgery.
* Patients 16 and over
* English speaking patients
* Patients who have the capacity to make their own medical decisions and consent to the study

Exclusion Criteria:

* Previous surgery on the operative knee
* Previous knee infection
* Chronic opioid use
* Have a known allergy to local anesthetics
* Patient using autograft (cadaver) for ACL reconstruction.

Where this trial is running

Maywood, Illinois

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Pain, PostoperativeAnterior Cruciate Ligament InjuriesAnalgesics, Opioid
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.