Using internal jugular vein variability to guide fluid replacement before surgery

Feasibility of Deep Inspiratory Internal Jugular Vein Variability in Guiding Preoperative Fluid Replacement：A Prospective, Randomized Controlled Study

This study is testing if using changes in the internal jugular vein during breathing can help doctors give the right amount of fluids before surgery to prevent low blood pressure.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 80 (estimated)
• Ages: 60 Years to 80 Years
• Sex: All
• Sponsor: Affiliated Hospital of Jiaxing University (other)
• Locations: 1 site (Jiaxing, Zhejiang)
• Trial ID: NCT06641505 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the feasibility of using deep inspiratory internal jugular vein variability to guide preoperative fluid replacement in patients undergoing surgery. It compares the incidence of hypotension during propofol induction between a group receiving variability-guided fluid infusion and a conventional fluid infusion group. The methodology involves ultrasound monitoring of the internal jugular vein during breathing cycles and observing changes in arterial blood pressure after propofol administration. The goal is to determine if this innovative approach can improve fluid management and reduce hypotension risks.

Who should consider this trial

Good fit: Ideal candidates are patients over 60 years old with ASA status II-III undergoing surgery that requires radial artery puncture and propofol induction.

Not a fit: Patients with a BMI of 30 or higher, previous hypotension, or those unable to take deep breaths may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to better fluid management and reduced incidence of hypotension during anesthesia induction for surgical patients.

How similar studies have performed: While this specific approach is novel, similar studies have shown that guided fluid management can improve outcomes in surgical patients.

Eligibility criteria

Inclusion Criteria:

* age over 60 years； American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ； Surgery with radial artery puncture； Propofol induction；

Exclusion Criteria:

* BMI≥30kg/m2； People with short necks； Previous hypotension (systolic blood pressure \<90mmHg or mean arterial pressure\<65mmHg)； Previous poorly controlled hypertension； Cardiac insufficiency , EF value\<50%； Upper limb deep vein thrombosis； History of radiotherapy or neck surgery； Inability to maintain a supine position for necessary measurements； Mechanical ventilation status or inability to take deep breaths patients； gastrointestinal surgery； Patients allergic to propofol； Restricted fluid intake；

Where this trial is running

Jiaxing, Zhejiang

• Affiliated Hospital of University — Jiaxing, Zhejiang, China (RECRUITING)

Study contacts

• Principal investigator: Qinghe Zhou — Affiliated Hospital of Jiaxing University
• Study coordinator: Qinghe Zhou

Conditions: Hemodynamic, Internal jugular vein, propofol, hemodynamic, hypotension, fluid replacement