Using inflammatory subtypes to personalize treatment for adults with ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational multicenter cohort approach enrolling adults with ARDS who require invasive mechanical ventilation within 72 hours of onset. Researchers will collect clinical data and blood biomarkers to classify patients into previously described inflammatory subphenotypes and apply statistical models to validate those classifications in this population. The study will compare organ dysfunction patterns, clinical trajectories, and real-world treatment responses between subphenotypes without altering standard care. Results will examine whether the inflammatory categories seen in prior trials reproduce in a Chinese ICU cohort and correlate with outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years.
2. ARDS with new Global definition.
3. Onset of ARDS within 72 hours.

Exclusion Criteria:

1. Refusal of informed consent by the patient's legally authorized representative.
2. Patients expected to die within 24 hours
3. Receiving extracorporeal membrane oxygenation at the time of recruitment

Where it's running

• Zhongda Hospital, School of Medicine, Southeast University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Hui Chen, MD
• Email: huichen.icu@gmail.com
• Phone: +8618006138640

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Full-Course ECMO Pathway for Moderate-to-Severe ARDS

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• Height measurement methods to guide ventilator settings in ARDS

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• Corticosteroids for a hyperinflammatory state in critical illness

  This trial tests whether methylprednisolone helps improve organ function and survival in adults with sepsis or ARDS who show a hyperinflammatory profile.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07511582

• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

  This project will follow adults with ARDS on mechanical ventilation to see how positive‑pressure breathing affects the right heart over time and how that relates to circulation.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT07450846

• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

  This trial tests whether IV umbilical‑cord mesenchymal stem cells, alone or with secretome, help adults with severe ARDS recover lung function and reduce inflammation.

  Recruiting Phase 1/2 PT. Prodia Stem Cell Indonesia · Jakarta Pusat, DKI Jakarta · NCT07439848

• Human umbilical cord mesenchymal stem cell injection for moderate to severe ARDS

  This will test whether a single injection of human umbilical cord mesenchymal stem cells can help adults with moderate to severe ARDS that hasn't improved after standard treatment.

  Recruiting Phase 1/2 Changchun Tuohua Pharmaceutical Co., Ltd. · Wuhan, Hubei · NCT07413978

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.