Using imaging to assess risk of lung injury in ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the Macklin effect as a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS), both related to COVID-19 and non-COVID-19 causes. The researchers will utilize artificial intelligence to identify imaging biomarkers that can non-invasively assess lung frailty in a mixed cohort of ARDS patients. By validating these biomarkers, the study seeks to develop a therapeutic algorithm to identify patients at high risk for barotrauma, ultimately improving management strategies for these individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical and radiological signs of ARDS, according to Berlin criteria \[14\], requiring ICU admission;
* Obtain duly signed informed consent.

Exclusion Criteria:

* Poor quality imaging (because of motion/respiratory artefacts).

Where it's running

• Ospedale Mater Domini
  Catanzaro, Calabria, Italy Recruiting
• IRCCS San Raffaele Scientific Institute
  Milan, Mi, Italy Recruiting

Study contacts

• Study coordinator: Diego Palumbo, MD
• Email: palumbo.diego@hsr.it
• Phone: +39022643

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Height measurement methods to guide ventilator settings in ARDS

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• Corticosteroids for a hyperinflammatory state in critical illness

  This trial tests whether methylprednisolone helps improve organ function and survival in adults with sepsis or ARDS who show a hyperinflammatory profile.

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• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

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• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

  This trial tests whether IV umbilical‑cord mesenchymal stem cells, alone or with secretome, help adults with severe ARDS recover lung function and reduce inflammation.

  Recruiting Phase 1/2 PT. Prodia Stem Cell Indonesia · Jakarta Pusat, DKI Jakarta · NCT07439848

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.